CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004026
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Growth regulation protein 
Protein Synonyms/Alias
  
Gene Name
 WHI2 
Gene Synonyms/Alias
 YOR043W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
371KRKSRLSKLADNVRSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2. 
Sequence Annotation
  
Keyword
 Cell cycle; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH YFITRDQLMS 60
LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD CFEYIMEIYT KAHDDLYNHP 120
VEKFFDRPSS SFVSNAKGFF GLSSNNSISS NNEQDILHQK PAIIVLREDL DYYCVPQEEF 180
QFDSTNEENN EDLLRHFMAQ VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS 240
SSNTKSTSKK LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN LTSGSTAPAT 360
ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD LVPKPNINAK LLLFWRKPAR 420
KCWWGEEDIE LEVEVFGSWK DESKKIIELI LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL 480
SVIGVQ 486 
Gene Ontology
 GO:0019211; F:phosphatase activator activity; IMP:SGD.
 GO:0007015; P:actin filament organization; IMP:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0000422; P:mitochondrion degradation; IMP:SGD.
 GO:0040008; P:regulation of growth; IMP:SGD.
 GO:0009408; P:response to heat; IMP:UniProtKB.
 GO:0009651; P:response to salt stress; IMP:UniProtKB. 
Interpro
 IPR011333; BTB/POZ_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS