UniProt Accession

 ZN397_HUMAN; Q8NF99; Q9BRM2 

Genbank Protein ID

 AF533250; AY157641; BC006172 

Genbank Nucleotide ID

 AAM95991.2; AAN65175.1; AAH06172.1 

Protein Name

 Zinc finger protein 397 

Protein Synonyms/Alias

 Zinc finger and SCAN domain-containing protein 15; Zinc finger protein 47 

Gene Name

 ZNF397 

Gene Synonyms/Alias

 ZNF47; ZSCAN15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	DNFSWDEKFKQNGST	ubiquitination	[1]
37	FSWDEKFKQNGSTQS	ubiquitination	[1]
55	LFRQQFRKFCYQETP	ubiquitination	[1]
225	HESNLVWKQGSATGE	ubiquitination	[1, 2, 3]
339	QRIHSGEKAYECSEC	ubiquitination	[1]
432	YECNECGKAFRQSSE	ubiquitination	[1]
516	YICNECGKAFRHRSV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Isoform 3 acts as a DNA-dependent transcriptional repressor. 

Sequence Annotation

 DOMAIN 50 132 SCAN box.
 ZN_FING 285 307 C2H2-type 1.
 ZN_FING 313 335 C2H2-type 2.
 ZN_FING 341 363 C2H2-type 3.
 ZN_FING 369 391 C2H2-type 4.
 ZN_FING 397 419 C2H2-type 5.
 ZN_FING 425 447 C2H2-type 6.
 ZN_FING 453 475 C2H2-type 7.
 ZN_FING 481 503 C2H2-type 8.
 ZN_FING 509 531 C2H2-type 9.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016032; P:viral reproduction; IEA:InterPro. 

Interpro

 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF02023; SCAN
 PF00096; zf-C2H2 

SMART

 SM00431; SCAN
 SM00355; ZnF_C2H2 

PROSITE

 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS