UniProt Accession

 CAPZB_RAT; Q5XI32 

Genbank Protein ID

 BC083861 

Genbank Nucleotide ID

 AAH83861.1 

Protein Name

 F-actin-capping protein subunit beta 

Protein Synonyms/Alias

 CapZ beta 

Gene Name

 Capzb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
78	YRSPWSNKYDPPLED	acetylation	[1]
95	MPSARLRKLEVEANN	acetylation	[1]
223	LVEDMENKIRSTLNE	acetylation	[1]
235	LNEIYFGKTKDIVNG	acetylation	[1]
235	LNEIYFGKTKDIVNG	ubiquitination	[2]
252	SVQTFADKSKQEALK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 235 235 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin capping; Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.