UniProt Accession

 PCCB_HUMAN; P05166; B7Z2Z4; Q16813; Q96CX0 

Genbank Protein ID

 X73424; S67325; AJ006487; AJ006488; AJ006489; AJ006490; AJ006491; AJ006492; AJ006493; AJ006494; AJ006495; AJ006496; AJ006497; AJ006498; AJ006499; AK295312; AC069524; CH471052; BC013768; BC053661; M13573; M31167; M31169 

Genbank Nucleotide ID

 CAA51825.1; AAB28900.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; CAA07066.1; BAH12030.1; EAW79118.1; AAH13768.1; AAH53661.1; AAA60036.1; AAA60037.1; AAA60038.1 

Protein Name

 Propionyl-CoA carboxylase beta chain, mitochondrial 

Protein Synonyms/Alias

 PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta 

Gene Name

 PCCB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	GMAADKNKFPGDSVV	ubiquitination	[1]
232	ITGPDVVKSVTNEDV	ubiquitination	[1, 2]
248	QEELGGAKTHTTMSG	ubiquitination	[1]
526	LDVLASKKVQRPWRK	acetylation	[3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 DOMAIN 38 531 Carboxyltransferase.
 REGION 325 358 Acyl-CoA binding (Potential).
 MOD_RES 60 60 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Ligase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004658; F:propionyl-CoA carboxylase activity; TAS:ProtInc.
 GO:0006635; P:fatty acid beta-oxidation; TAS:Reactome.
 GO:0019626; P:short-chain fatty acid catabolic process; TAS:Reactome. 

Interpro

 IPR000022; Carboxyl_trans.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N. 

Pfam

 PF01039; Carboxyl_trans 

SMART

  

PROSITE

 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER 

PRINTS