CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Armadillo repeat-containing protein 10 
Protein Synonyms/Alias
 Splicing variant involved in hepatocarcinogenesis protein 
Gene Name
 ARMC10 
Gene Synonyms/Alias
 SVH; PSEC0198 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44ELGIRSSKSAGALEEubiquitination[1]
146GIPIVANKINHSNQSubiquitination[2]
155NHSNQSIKEKALNALubiquitination[1]
335HDAEVKEKVVTIIPKubiquitination[2]
342KVVTIIPKI******ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. 
Sequence Annotation
 REPEAT 138 180 ARM.
 MOD_RES 45 45 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Growth regulation; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 343 AA 
Protein Sequence
MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 60
RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 120
LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS 180
QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK 240
LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 300
PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI 343 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR006911; ARM-rpt_dom.
 IPR016024; ARM-type_fold. 
Pfam
 PF04826; Arm_2 
SMART
  
PROSITE
 PS50176; ARM_REPEAT 
PRINTS