| Tag | Content |
|---|
| CPLM ID | CPLM-016407 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane protein 127 |
Protein Synonyms/Alias | |
Gene Name | Tmem127 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | PGSSALPKQPERSLA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1 (By similarity). May act as a tumor suppressor (By similarity). |
Sequence Annotation | MOD_RES 17 17 Phosphoserine (By similarity). |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 238 AA |
Protein Sequence | MYAPGGAGLP GGRRRRSPGS SALPKQPERS LASALPGALS ITALCTALAE PAWLHIHGGT 60
CSRQELGVSD VLGYVNPDLL KDFCMNPQTV LLLRVIAAFC FLGILCSLSA FLLDVFGPKH 120
PALKITRRYA FAHILTVLQC ATVIGFSYWA SELILAQQQQ HKKYHGSQVY VTFAVSFYLV 180
AGAGGASILA TAANLLRHYP TEEEEQALEL LSEMEENDPY PAEYEVINQF QPPPAYTP 238 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. GO:0032007; P:negative regulation of TOR signaling cascade; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |