CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006756
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoglycerate transport system sensor protein PgtB 
Protein Synonyms/Alias
  
Gene Name
 pgtB 
Gene Synonyms/Alias
 STM2397 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
279LLEIGMVKNKMPDTMacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. 
Sequence Annotation
 DOMAIN 364 416 HAMP.
 DOMAIN 454 663 Histidine kinase.
 MOD_RES 457 457 Phosphohistidine; by autocatalysis (By  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
MKGRLLQRLR QLSISNSLRG AFLTGALLTL IVSMVSLYSW HEQSSQVRYS LDEYFPRIHS 60
AFLIEGNLNL AVDQLNEFLL APNTTVRLQL RTQIIQHLDK IERLSQGLQL AERRQLAVIL 120
QDSRTLLAEL DNALYNMFLV REKVSELSAR IDWLHDDFTT ELNSLVQDFT WQQGTLLDQI 180
EANQGDAAQY LQRSREVQNE QQQVYTLARI ENQIVDDLRD RLNELKSGNN DGMLVETHIR 240
YLENLKKTAD ENIRALDDWP STITLRQTID ELLEIGMVKN KMPDTMRDYV AAQKALLDAS 300
RAREATLGRF RTLLEAQLGS SHQQMQTFNQ RLEQIVRVSG GLILVATLLA LLLAWGLNHY 360
FIRSRLVKRF TALNQAVVQI GLGRTDSTIP VYGRDELGRI ARLLRHTLGQ LNMQRRQLEQ 420
EVAERKEIEA DLRAMQDELI QTAKLAVVGQ TMTTLAHEIN QPLNALSMYL FTAGRAIEQG 480
QSGQARNTLT KAEGLINRID AIIRSLRQFT RRAELETPLY PVDLRQTFVA AWELLAMRHQ 540
SRQGALSLPT DTVWVSGDEV RIQQVLVNVL ANALDACSHD AVIAVTWQTQ GEALEVYIAD 600
NGPGWPVALL PSLLKPFTTS KAVGLGIGLS ISVSLMAQMK GDLRLASTLT RNACVVLQFS 660
VTDVDDVE 668 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 
Interpro
 IPR003660; HAMP_linker_domain.
 IPR003594; HATPase_ATP-bd.
 IPR003661; Sig_transdc_His_kin_sub1_dim/P.
 IPR005467; Sig_transdc_His_kinase_core.
 IPR009082; Sig_transdc_His_kinase_dimeric.
 IPR017116; Sig_transdc_His_kinase_PgtB. 
Pfam
 PF00672; HAMP
 PF02518; HATPase_c
 PF00512; HisKA 
SMART
 SM00304; HAMP
 SM00387; HATPase_c
 SM00388; HisKA 
PROSITE
 PS50885; HAMP
 PS50109; HIS_KIN 
PRINTS