CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013757
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pirin 
Protein Synonyms/Alias
 Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase 
Gene Name
 Pir 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
46FLLFDEFKGGRPGGFacetylation[1]
234QLENKDPKRSHFVLIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity). 
Sequence Annotation
 METAL 56 56 Iron (By similarity).
 METAL 58 58 Iron (By similarity).
 METAL 101 101 Iron (By similarity).
 METAL 103 103 Iron (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Nucleus; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MASSKKVTLS VLSREQSEGV GARVRRSIGG PELKMLDPFL LFDEFKGGRP GGFPDHPHRG 60
FETVSYLLEG GSMAHEDFCG HVGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL 120
KRSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDQGA 180
KHSQPIPKGW TSFIYTISGD VYIGPDDAQQ KIEPHRTAVL GEGDTVQLEN KDPKRSHFVL 240
IAGEPLREPV VQHGPFVMNT NEEISEAILD FRNAKNGFEG AKTWKSKIGN Q 291 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; ISS:UniProtKB.
 GO:0008127; F:quercetin 2,3-dioxygenase activity; ISS:UniProtKB.
 GO:0030224; P:monocyte differentiation; IEA:Compara. 
Interpro
 IPR012093; Pirin.
 IPR008778; Pirin_C_dom.
 IPR003829; Pirin_N_dom.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 
Pfam
 PF02678; Pirin
 PF05726; Pirin_C 
SMART
  
PROSITE
  
PRINTS