UniProt Accession

 D3Z1C5_MOUSE; D3Z1C5 

Genbank Protein ID

 AC140233 

Genbank Nucleotide ID

  

Protein Name

 LIM domain-binding protein 1 

Protein Synonyms/Alias

  

Gene Name

 Ldb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
159	FDDMMRIKTWHFSIR	acetylation	[1]
241	LKTCLFQKWQRMVAP	acetylation	[2]
241	LKTCLFQKWQRMVAP	ubiquitination	[3]
355	ANSPWNSKPPSSQES	acetylation	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043234; C:protein complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0001158; F:enhancer sequence-specific DNA binding; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0003712; F:transcription cofactor activity; IEA:InterPro.
 GO:0000989; F:transcription factor binding transcription factor activity; IPI:MGI.
 GO:0009948; P:anterior/posterior axis specification; IMP:MGI.
 GO:0022607; P:cellular component assembly; IGI:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0010669; P:epithelial structure maintenance; IGI:MGI.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0001942; P:hair follicle development; IGI:MGI.
 GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0035019; P:somatic stem cell maintenance; IGI:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IMP:MGI. 

Interpro

 IPR002691; LIM-dom-bd. 

Pfam

  

SMART

  

PROSITE

  

PRINTS