UniProt Accession

 F5GXC0_HUMAN; F5GXC0 

Genbank Protein ID

 AC007570 

Genbank Nucleotide ID

  

Protein Name

 Mevalonate kinase 

Protein Synonyms/Alias

  

Gene Name

 MVK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	SLPNIGIKRAWDVAR	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004496; F:mevalonate kinase activity; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. 

Interpro

 IPR006204; GHMP_kinase_N_dom.
 IPR006203; GHMP_knse_ATP-bd_CS.
 IPR006205; Mev_gal_kin.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

 PS00627; GHMP_KINASES_ATP 

PRINTS

 PR00959; MEVGALKINASE.