CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002517
UniProt Accession
Genbank Protein ID
 M14634 
Genbank Nucleotide ID
Protein Name
 Propionyl-CoA carboxylase beta chain, mitochondrial 
Protein Synonyms/Alias
 PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta 
Gene Name
 Pccb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62RRIDAQHKRGKLTARacetylation[1]
103GMAAEKNKFPGDSVVacetylation[1]
435KITVITRKAYGGAYDacetylation[1]
528LEVLASKKVHRPWRKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 DOMAIN 40 533 Carboxyltransferase.
 REGION 327 360 Acyl-CoA binding (Potential).
 MOD_RES 62 62 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MAAVIRIRAM AAGTRLRVLN CGLGTTIRSL CSQPVSVNER IENKRHAALL GGGQRRIDAQ 60
HKRGKLTARE RISLLLDPGS FLESDMFVEH RCADFGMAAE KNKFPGDSVV TGRGRINGRL 120
VYVFSQDFTV FGGSLSGAHA QKICKIMDQA ITVGAPVIGL NDSGGARIQE GVESLAGYAD 180
IFLRNVTASG VIPQISLIMG PCAGGAVYSP ALTDFTFMVK DTSYLFITGP EFVKSVTNED 240
VTQEQLGGAK THTTVSGVAH RAFDNDVDAL CNLREFLNFL PLSNQDPASI RECHDPSDRL 300
VPELDTVVPL ESSKAYNMLD IIHAVIDERE FFEIMPNYAK NIVIGFARMN GRTVGIVGNQ 360
PNVASGCLDI NSSVKGARFV RFCDAFSIPL ITFVDVPGFL PGTAQEYGGI IRHGAKLLYA 420
FAEATVPKIT VITRKAYGGA YDVMSSKHLL GDTNYAWPTA EIAVMGAKGA VEIIFKGHED 480
VEAAQAEYVE KFANPFPAAV RGFVDDIIQP SSTRARICCD LEVLASKKVH RPWRKHANVP 540
L 541 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; TAS:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004658; F:propionyl-CoA carboxylase activity; TAS:RGD.
 GO:0009063; P:cellular amino acid catabolic process; TAS:RGD.
 GO:0009062; P:fatty acid catabolic process; TAS:RGD. 
Interpro
 IPR000022; Carboxyl_trans.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N. 
Pfam
 PF01039; Carboxyl_trans 
SMART
  
PROSITE
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER 
PRINTS