UniProt Accession

 HRSL3_HUMAN; P53816; B2R7Q4; B7XAK5; Q3SYI3; Q9HDD1 

Genbank Protein ID

 X92814; AB030814; AF317086; AB439591; AK313075; CH471076; BC001387; BC103807 

Genbank Nucleotide ID

 CAA63423.1; BAB08108.1; AAL26892.1; BAH08749.1; BAG35901.1; EAW74158.1; AAH01387.1; AAI03808.1 

Protein Name

 HRAS-like suppressor 3 

Protein Synonyms/Alias

 HRSL3; Adipose-specific phospholipase A2; AdPLA; Group XVI phospholipase A1/A2; H-rev 107 protein homolog; HRAS-like suppressor 1; HREV107-1; HREV107-3; Renal carcinoma antigen NY-REN-65 

Gene Name

 PLA2G16 

Gene Synonyms/Alias

 HRASLS3; HREV107 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	YDVAGSDKYQVNNKH	ubiquitination	[1]
91	YSPLPCSKIIQRAEE	ubiquitination	[1, 2]
107	VGQEVLYKLTSENCE	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. 

Sequence Annotation

 ACT_SITE 23 23
 ACT_SITE 35 35
 ACT_SITE 113 113 Acyl-thioester intermediate.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 162 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0052740; F:1-acyl-2-lysophosphatidylserine acylhydrolase activity; IEA:EC.
 GO:0008970; F:phosphatidylcholine 1-acylhydrolase activity; IEA:EC.
 GO:0052739; F:phosphatidylserine 1-acylhydrolase activity; IEA:EC.
 GO:0004623; F:phospholipase A2 activity; IDA:UniProtKB.
 GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0036151; P:phosphatidylcholine acyl-chain remodeling; TAS:Reactome.
 GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; TAS:Reactome.
 GO:0036149; P:phosphatidylinositol acyl-chain remodeling; TAS:Reactome.
 GO:0036150; P:phosphatidylserine acyl-chain remodeling; TAS:Reactome. 

Interpro

 IPR007053; LRAT-like_dom. 

Pfam

 PF04970; LRAT 

SMART

  

PROSITE

  

PRINTS