CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrator complex subunit 8 
Protein Synonyms/Alias
  
Gene Name
 INTS8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191VLRELFKKAQQGNEAubiquitination[1]
252SRSVNLEKASESLKGubiquitination[1, 2]
258EKASESLKGNMAAFLubiquitination[1, 2]
297LLKDEERKLLVDQMRubiquitination[1]
524QLLAATCKELPGPKEubiquitination[1]
565DGRVSLIKQRESTLGubiquitination[1]
715FLREIDYKTAFKSLQubiquitination[1]
764DKRQIAIKAIGQTELubiquitination[2]
790AAQRRKKKFLQAMAKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 800 AA 
Protein Sequence
XEKELTENIL KVLKEQAADS ILVLEAALKL NKDLYVHTMR TLDLLAMEPG MVNGETESST 60
AGLKVKTEEM QCQVCYDLGA AYFQQGSTNS AVYENAREKF FRTKELIAEI GSLSLHCTID 120
EKRLAGYCQA CDVLVPSSDS TSQQLTPYSQ VHICLRSGNY QEVIQIFIED NLTLSLPVQF 180
RQSVLRELFK KAQQGNEALD EICFKVCACN TVRDILEGRT ISVQFNQLFL RPNKEKIDFL 240
LEVCSRSVNL EKASESLKGN MAAFLKNVCL GLEDLQYVFM ISSHELFITL LKDEERKLLV 300
DQMRKRSPRV NLCIKPVTSF YDIPASASVN IGQLEHQLIL SVDPWRIRQI LIELHGMTSE 360
RQFWTVSNKW EVPSVYSGVI LGIKDNLTRD LVYILMAKGL HCSTVKDFSH AKQLFAACLE 420
LVTEFSPKLR QVMLNEMLLL DIHTHEAGTG QAGERPPSDL ISRVRGYLEM RLPDIPLRQV 480
IAEECVAFML NWRENEYLTL QVPAFLLQSN PYVKLGQLLA ATCKELPGPK ESRRTAKDLW 540
EVVVQICSVS SQHKRGNDGR VSLIKQREST LGIMYRSELL SFIKKLREPL VLTIILSLFV 600
KLHNVREDIV NDITAEHISI WPSSIPNLQS VDFEAVAITV KELVRYTLSI NPNNHSWLII 660
QADIYFATNQ YSAALHYYLQ AGAVCSDFFN KAVPPDVYTD QVAILCQFLR EIDYKTAFKS 720
LQEQNSHDAM DSYYDYIWDV TILEYLTYLH HKRGETDKRQ IAIKAIGQTE LNASNPEEVL 780
QLAAQRRKKK FLQAMAKLYF 800 
Gene Ontology
  
Interpro
 IPR011990; TPR-like_helical. 
Pfam
  
SMART
  
PROSITE
  
PRINTS