CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039865
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase PRP4 homolog 
Protein Synonyms/Alias
  
Gene Name
 PRPF4B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156RSSSTKGKLELVDNKacetylation[1]
642LRAAGIGKDFKENPNacetylation[1, 2]
671NIGEVLDKRYNVYGYacetylation[1]
723LKELEFLKKLNDADPacetylation[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 993 AA 
Protein Sequence
MEDANSEKSI NEENGEVSED QSQNKHSRHK KKKHKHRSKH KKHKHSSEED KDKKHKHKHK 60
HKKHKRKEII DASDKEGMSP AKRTKLDDLA LLEDLEKQRA LIKAELDNEL MEGKVQSGMG 120
LILQGYESGS EEEGEIHEKA RNGNRSSTRS SSTKGKLELV DNKITTKKRS KSRSKERTRH 180
RSDKKKSKGG IEIVKEKTTR SKSKERKKSK SPSKRSKSQD QARKSKSPTL RRRSQEKIGK 240
ARSPTDDKVK IEDKSKSKDR KKSPIINESR SRDRGKKSRS PVDLRGKSKD RRSRSKERKS 300
KRSETDKEKK PIKSPSKDAS SGKENRSPSR RPGRSPKRRS LSPKPRDKSR RSRSPLLNDR 360
RSKQSKSPSR TLSPGRRAKS RSLERKRREP ERRRLSSPRT RPRDDILSRR ERSKDASPIN 420
RWSPTRRRSR SPIRRRSRSP LRRSRSPRRR SRSPRRRDRG RRSRSRLRRR SRSRGGRRRR 480
SRSKVKEDKF KGSLSEGMKV EQESSSDDNL EDFDVEEEDE EALIEQRRIQ RQAIVQKYKY 540
LAEDSNMSVP SEPSSPQSST RTRSPSPDDI LERVAADVKE YERENVDTFE ASVKAKHNLM 600
TVEQNNGSSQ KKLLAPDMFT ESDDMFAAYF DSARLRAAGI GKDFKENPNL RDNWTDAEGY 660
YRVNIGEVLD KRYNVYGYTG QGVFSNVVRA RDNARANQEV AVKIIRNNEL MQKTGLKELE 720
FLKKLNDADP DDKFHCLRLF RHFYHKQHLC LVFEPLSMNL REVLKKYGKD VGLHIKAVRS 780
YSQQLFLALK LLKRCNILHA DIKPDNILVN ESKTILKLCD FGSASHVADN DITPYLVSRF 840
YRAPEIIIGK SYDYGIDMWS VGCTLYELYT GKILFPGKTN NHMLKLAMDL KGKMPNKMIR 900
KGVFKDQHFD QNLNFMYIEV DKVTEREKVT VMSTINPTKD LLADLIGCQR LPEDQRKKVH 960
QLKDLLDQIL MLDPAKRISI NQALQHAFIQ EKI 993 
Gene Ontology
 GO:0005694; C:chromosome; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS