UniProt Accession

 Q5SQB0_MOUSE; Q5SQB0 

Genbank Protein ID

 AL772409 

Genbank Nucleotide ID

  

Protein Name

 Nucleophosmin 

Protein Synonyms/Alias

  

Gene Name

 Npm1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	GCELKADKDYHFKVD	acetylation	[1, 2, 3]
32	ADKDYHFKVDNDENE	acetylation	[2, 3, 4]
32	ADKDYHFKVDNDENE	ubiquitination	[5]
54	VSLGAGAKDELHIVE	acetylation	[2]
54	VSLGAGAKDELHIVE	ubiquitination	[5]
209	EKTPKTPKGPSSVED	acetylation	[3]
209	EKTPKTPKGPSSVED	succinylation	[3]
209	EKTPKTPKGPSSVED	ubiquitination	[5]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0001652; C:granular component; IDA:MGI.
 GO:0015934; C:large ribosomal subunit; IDA:MGI.
 GO:0016607; C:nuclear speck; IDA:MGI.
 GO:0015935; C:small ribosomal subunit; IDA:MGI.
 GO:0043023; F:ribosomal large subunit binding; ISO:MGI.
 GO:0043024; F:ribosomal small subunit binding; ISO:MGI.
 GO:0019843; F:rRNA binding; IDA:MGI.
 GO:0016049; P:cell growth; IDA:MGI.
 GO:0006884; P:cell volume homeostasis; IDA:MGI.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0031328; P:positive regulation of cellular biosynthetic process; IDA:MGI.
 GO:0010825; P:positive regulation of centrosome duplication; IGI:MGI.
 GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0051259; P:protein oligomerization; ISO:MGI.
 GO:0043516; P:regulation of DNA damage response, signal transduction by p53 class mediator; IGI:MGI.
 GO:0042273; P:ribosomal large subunit biogenesis; IMP:MGI.
 GO:0000055; P:ribosomal large subunit export from nucleus; IMP:MGI.
 GO:0042274; P:ribosomal small subunit biogenesis; IMP:MGI.
 GO:0000056; P:ribosomal small subunit export from nucleus; IDA:MGI.
 GO:0006407; P:rRNA export from nucleus; IDA:MGI. 

Interpro

 IPR004301; Nucleoplasmin.
 IPR024057; Nucleoplasmin_core_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS