CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-mRNA-processing factor 39 
Protein Synonyms/Alias
 PRP39 homolog 
Gene Name
 PRPF39 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
248SHHFQRFKEHVQNNLubiquitination[1]
346KRPYFHVKPLEKAQLacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Involved in pre-mRNA splicing (By similarity). 
Sequence Annotation
 REPEAT 109 141 HAT 1.
 REPEAT 143 175 HAT 2.
 REPEAT 183 218 HAT 3.
 REPEAT 220 253 HAT 4.
 REPEAT 333 365 HAT 5.
 REPEAT 367 399 HAT 6.
 REPEAT 404 436 HAT 7.  
Keyword
 Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
MQNSHMDEYR NSSNGSTGNS SEVVVEHPTD FSTEIMNVTE MEQSPDDSPN VNASTEETEM 60
ASAVDLPVTL TETEANFPPE YEKFWKTVEN NPQDFTGWVY LLQYVEQENH LMAARKAFDR 120
FFIHYPYCYG YWKKYADLEK RHDNIKPSDE VYRRGLQAIP LSVDLWIHYI NFLKETLDPG 180
DPETNNTIRG TFEHAVLAAG TDFRSDRLWE MYINWENEQG NLREVTAIYD RILGIPTQLY 240
SHHFQRFKEH VQNNLPRDLL TGEQFIQLRR ELASVNGHSG DDGPPGDDLP SGIEDITDPA 300
KLITEIENMR HRIIEIHQEM FNYNEHEVSK RWTFEEGIKR PYFHVKPLEK AQLKNWKEYL 360
EFEIENGTHE RVVVLFERCV ISCALYEEFW IKYAKYMENH SIEGVRHVFS RACTIHLPKK 420
PMVHMLWAAF EEQQGNINEA RNILKTFEEC VLGLAMVRLR RVSLERRHGN LEEAEHLLQD 480
AIKNAKSNNE SSFYAVKLAR HLFKIQKNLP KSRKVLLEAI ERDKENTKLY LNLLEMEYSG 540
DLKQNEENIL NCFDKAVHGS LPIKMRITFS QRKVEFLEDF GSDVNKLLNA YDEHQTLLKE 600
QDSLKRKAEN GSEEPEEKKA HTEDTTSSST QMIDGDLQAN QAVYNYSAWY QYNYQNPWNY 660
GQYYPPPPT 669 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR003107; HAT.
 IPR011990; TPR-like_helical. 
Pfam
  
SMART
 SM00386; HAT 
PROSITE
  
PRINTS