CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016032
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polycomb protein Suz12 
Protein Synonyms/Alias
 Suppressor of zeste 12 protein homolog 
Gene Name
 Suz12 
Gene Synonyms/Alias
 D11Ertd530e; Kiaa0160 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
377KSTAPVAKPLATRNSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. 
Sequence Annotation
 ZN_FING 450 473 C2H2-type.
 REGION 565 641 VEFS-box.
 MOD_RES 548 548 Phosphoserine (By similarity).
 MOD_RES 585 585 Phosphoserine (By similarity).
 CROSSLNK 74 74 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 75 75 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 77 77 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Chromatin regulator; Chromosome; Complete proteome; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 741 AA 
Protein Sequence
MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA AVAAAASGGK SGGGGCGGGG SYSASSSSAA 60
AAAAAAGAAV LPVKKPKMEH VQADHELFLQ AFEKPTQIYR FLRTRNLIAP IFLHRTLTYM 120
SHRNSRTSIK RKTFKVDDML SKVEKMKGEQ ESHSLSAHLQ LTFTGFFHKN DKPSQNSENE 180
QNSVTLEVLL VKVCHKKRKD VSCPIRQVPT GKKQVPLNPD LNQTKPGNFP SLAVSSNEFE 240
PSNSHMVKSY SLLFRVTRPG RREFNGMING ETNENIDVSE ELPARRKRNR EDGEKTFVAQ 300
MTVFDKNRRL QLLDGEYEVA MQEMEECPIS KKRATWETIL DGKRLPPFET FSQGPTLQFT 360
LRWTGETNDK STAPVAKPLA TRNSESLHQE NKPGSVKPAQ TIAVKETLTT ELQTRKEKDN 420
SNESRQKLRI FYQFLYNNNT RQQTEARDDL HCPWCTLNCR KLYSLLKHLK LCHSRFIFNY 480
VYHPKGARID VSINECYDGS YAGNPQDIHR QPGFAFSRNG PVKRTPITHI LVCRPKRTKA 540
SMSEFLESED GEVEQQRTYS SGHNRLYFHS DTCLPLRPQE MEVDSEDEKD PEWLREKTIT 600
QIEEFSDVNE GEKEVMKLWN LHVMKHGFIA DNQMNHACML FVENYGQKII KKNLCRNFML 660
HLVSMHDFNL ISIMSIDKAV TKLREMQQKL EKGESATPSN EEIAEEQNGT ANGFSETNSK 720
EKALETDGVS GVPKQSKKQK L 741 
Gene Ontology
 GO:0035098; C:ESC/E(Z) complex; IDA:UniProtKB.
 GO:0001739; C:sex chromatin; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0042054; F:histone methyltransferase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0016571; P:histone methylation; IMP:MGI.
 GO:0016574; P:histone ubiquitination; IMP:MGI.
 GO:0045596; P:negative regulation of cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR019135; Polycomb_protein_VEFS-Box.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF09733; VEFS-Box 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS