CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018110
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Echinoderm microtubule-associated protein-like 3 
Protein Synonyms/Alias
 EMAP-3 
Gene Name
 Eml3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
578ELLVGTTKNALLRGDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). 
Sequence Annotation
 REPEAT 304 353 WD 1.
 REPEAT 358 401 WD 2.
 REPEAT 404 443 WD 3.
 REPEAT 458 496 WD 4.
 REPEAT 513 552 WD 5.
 REPEAT 596 635 WD 6.
 REPEAT 679 718 WD 7.
 REPEAT 725 764 WD 8.
 REPEAT 838 878 WD 9.
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 882 882 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 897 AA 
Protein Sequence
MDGAAGPGEG PAHETLQTLS QRLRVQEEEM ELVKAALAEA LRLLRLHGST TTLQGSGISA 60
PTRNSSITVP PGLPPTCSPS LVTRGTQTEE ELEIVPSSGP PGLSNGPPAL QGGSEEPSGT 120
QSEGGCSSSS GAGSPGPPGI LRPVQPLQRS DTPRRNSSSS SSPSERPRQK LSRKAASSAN 180
LLLRSGSTES RGNKDPLSSP GGPGSRRSNY NLEGISVKMF LRGRPITMYI PSGIRSLEEL 240
PSGPPPETLS LDWVYGYRGR DSRSNLFVLR SGEVVYFIAC VVVLYRPGGG PGGPGGGGQR 300
HYRGHTDCVR CLAVHPDGVR VASGQTAGVD KDGKPLQPVV HIWDSETLLK LQEIGLGAFE 360
RGVGALAFSA ADQGAFLCVV DDSNEHMLSV WDCSRGVKLA EIKSTNDSVL AVGFSPRDSS 420
CIVTSGKSHV HFWNWSGGTG APGNGLLARK QGVFGKYKKP KFIPCFVFLP DGDILTGDSE 480
GNILTWGRSV SDSKTPGRGG AKETYTIVAQ AHAHEGSIFA LCLRRDGTVL SGGGRDRRLV 540
QWGPGLVALQ EAEIPEHFGA VRAIAEGLGS ELLVGTTKNA LLRGDLAQGF SPVIQGHTDE 600
LWGLCTHPSQ NRFLTCGHDR QLCLWDGEGH ALAWSMDLKE TGLCADFHPS GAVVVVGLNT 660
GRWLVLDTET REIVSDVTDG NEQLSVVRYS PDGLYLAIGS HDNMIYIYSV SSCGTKSSRF 720
GRCMGHSSFI THLDWSKDGN FIMSNSGDYE ILYWDVAGGC KLLRNRYESR DREWATYTCV 780
LGFHVYGVWP DGSDGTDINS LCRSHNERVV AVADDFCKVH LFQYPCARAK APSRMYSGHG 840
SHVTSVRFTH DDSYLVSLGG KDASIFQWRV LGAGSSGPAP ATPSRTPSLS PASSLDV 897 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR005108; HELP.
 IPR004106; Peptidase_S9A_B_C_N.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03451; HELP
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS