UniProt Accession

 RRAGB_HUMAN; Q5VZM2; A8K042; Q15348; Q8N3T0 

Genbank Protein ID

 X90530; AK289407; AL831926; AL139277; AL159987; AL139277; AL159987; AL159987; AL139277; AL159987; AL139277; CH471154; BC034726 

Genbank Nucleotide ID

 CAA62132.1; BAF82096.1; CAD38586.1; CAI40804.1; CAI40804.1; CAI40805.1; CAI40805.1; CAH70826.1; CAH70826.1; CAH70827.1; CAH70827.1; EAW93229.1; AAH34726.1 

Protein Name

 Ras-related GTP-binding protein B 

Protein Synonyms/Alias

 Rag B; RagB 

Gene Name

 RRAGB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	KKVLLMGKSGSGKTS	ubiquitination	[1]
203	DQRDLIFKEREEDLR	ubiquitination	[1]
291	RDAHRFEKISNIIKQ	ubiquitination	[2, 3]
305	QFKLSCSKLAASFQS	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. 

Sequence Annotation

 NP_BIND 47 54 GTP (By similarity).
 NP_BIND 123 127 GTP (By similarity).
 NP_BIND 188 191 GTP (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; GTP-binding; Lysosome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005525; F:GTP binding; IDA:HGNC.
 GO:0034613; P:cellular protein localization; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB. 

Interpro

 IPR006762; Gtr1_RagA.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04670; Gtr1_RagA 

SMART

  

PROSITE

  

PRINTS