CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase 
Protein Synonyms/Alias
  
Gene Name
 Tyk2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
776EGTNPFIKLSDPGVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1207 AA 
Protein Sequence
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE 60
VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP 120
QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP 180
QGKHEFMNDV VSLRDLSSEE EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC 240
IPHSFRQHIR QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER 300
IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI QWHPLQTQES 360
ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC DFQDISHVVL KERRVHIHLQ 420
DNKCLLLCLC SQAEALSFVA LVDGYFRLTA DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP 480
FVQAKLWPED GLYLIQWSTS HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD 540
GWGRSFASLG DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS 600
QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG GTSGQQLRVV 660
LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG SENIIVTEFV EHGPLDVWLR 720
RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL VHGNVCGRNI LLARLGLEEG TNPFIKLSDP 780
GVGQGALSRE ERVERIPWTA PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP 840
SEKERFYTKK HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV 900
NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKEGCGPQL 960
RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHCVGLAQL 1020
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED 1080
GDSPVFWYAP ECLKECKFYY ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT 1140
VLRLTELLER GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV 1200
PSVFSVC 1207 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR000299; FERM_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
 IPR016045; Tyr_kinase_non-rcpt_TYK2_N. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
 SM00295; B41
 SM00252; SH2
 SM00219; TyrKc 
PROSITE
 PS50057; FERM_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR01823; JANUSKINASE.
 PR00109; TYRKINASE.
 PR01827; YKINASETYK2.