CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HBS1-like protein 
Protein Synonyms/Alias
  
Gene Name
 Hbs1l 
Gene Synonyms/Alias
 Hbs1; Kiaa1038 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
103ILTEAILKHKFDVQKubiquitination[1]
422RFQEITGKLGHFLKQubiquitination[1]
570GCIFCGPKEPIKACTubiquitination[1]
620RLISVLNKSTGEVTKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 NP_BIND 265 272 GTP (By similarity).
 NP_BIND 342 346 GTP (By similarity).
 NP_BIND 404 407 GTP (By similarity).
 MOD_RES 113 113 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 682 AA 
Protein Sequence
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDNPEE EYGYEDLRES 60
SNSLLNHQLS EIDQARLYSC LDHMREVLGD AVPDDILTEA ILKHKFDVQK ALSVVLEQDG 120
VQPWKEKSER AVCAGQPSKG KSVISRSSQS ESEIVPKVAK MTVSGKKQTM GFEVPGLTSE 180
ENGLSVRAPH KGPPGDDVSV ASPNIPETGT PKSALPPPSL QTSEELGSTP TPVRKSGKLR 240
QQIDVKAELE KRQGGKQLLN LVVIGHVDAG KSTLMGHMLY LLGNVNKRTM HKYEQESKKA 300
GKASFAYAWV LDETGEERER GVTMDVGMTK FETTTKVITL MDAPGHKDFI PNMITGAAQA 360
DVAVLVVDAS RGEFEAGFET GGQTREHGLL VRSLGVTQLA VAVNKMDQVN WQQERFQEIT 420
GKLGHFLKQA GFKESDVAFI PTSGLSGENL TARSQSSDLT TWYKGMCLLE QIDSFKPPQR 480
SIDKPFRLCV SDVFKDQGSG FCVTGKIEAG YIQTGDRLLA MPPNETCTAK GITLHDEPVD 540
WAAAGDHVNL TLVGMDIIKI NVGCIFCGPK EPIKACTRFR ARILVFNIEV PITKGFPVLL 600
HYQTVSEPAV IKRLISVLNK STGEVTKKKP KLLTKGQNAL VELQTQRPVA LELYKDFKEL 660
GRFMLRYGGS TVAAGVVTEI KE 682 
Gene Ontology
 GO:0005525; F:GTP binding; ISS:MGI.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR015033; DUF1916.
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF08938; DUF1916
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.