UniProt Accession

 ARGI_YEAST; P00812; D6W3Q6 

Genbank Protein ID

 M10414; U43503; M10110; BK006949 

Genbank Nucleotide ID

 AAA34470.1; AAB68250.1; AAA34469.1; DAA11322.1 

Protein Name

 Arginase 

Protein Synonyms/Alias

  

Gene Name

 CAR1 

Gene Synonyms/Alias

 YPL111W; LPH15W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
11	GPHYNYYKNRELSIV	acetylation	[1]
28	PFSGGQGKLGVEKGP	acetylation	[1]
88	SVMIDGVKAKRADLV	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 REGION 148 152 Substrate binding (By similarity).
 REGION 159 161 Substrate binding (By similarity).
 METAL 123 123 Manganese 1 (By similarity).
 METAL 146 146 Manganese 1 (By similarity).
 METAL 146 146 Manganese 2 (By similarity).
 METAL 148 148 Manganese 2 (By similarity).
 METAL 150 150 Manganese 1 (By similarity).
 METAL 256 256 Manganese 1 (By similarity).
 METAL 256 256 Manganese 2 (By similarity).
 METAL 258 258 Manganese 2 (By similarity).
 BINDING 205 205 Substrate (By similarity).
 BINDING 301 301 Substrate (By similarity).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 77 77 Phosphothreonine.
 MOD_RES 270 270 Phosphothreonine.  

Keyword

 Arginine metabolism; Complete proteome; Hydrolase; Manganese; Metal-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004053; F:arginase activity; IDA:SGD.
 GO:0030145; F:manganese ion binding; IDA:SGD.
 GO:0090369; F:ornithine carbamoyltransferase inhibitor activity; IMP:SGD.
 GO:0008270; F:zinc ion binding; IDA:SGD.
 GO:0019547; P:arginine catabolic process to ornithine; IDA:SGD.
 GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR014033; Arginase.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 

Pfam

 PF00491; Arginase 

SMART

  

PROSITE

 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 

PRINTS

 PR00116; ARGINASE.