CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024764
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitogen-activated protein kinase kinase kinase 19 
Protein Synonyms/Alias
 SPS1/STE20-related protein kinase YSK4 
Gene Name
 Map3k19 
Gene Synonyms/Alias
 Ysk4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
594RAPLTEKKSTHQTQKacetylation[1]
612QAFPRIGKHAGIKKPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 DOMAIN 1044 1307 Protein kinase.
 NP_BIND 1050 1058 ATP (By similarity).
 ACT_SITE 1169 1169 Proton acceptor (By similarity).
 BINDING 1072 1072 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1311 AA 
Protein Sequence
MDSMPRPERH AESLLDICHE AGSTPMEMTV SQTENLTLQS ISSSEDFDLE DDFSPFILAR 60
EGAAPRGENW PRRTEGVEII VTFPPDPLQE ASQEDLKESN QVTSEHQERE QVHPVSPPDD 120
AEMVGLTGRM LTTQPSLLKT DGSSEELCGV DVALSPPRPC LDSSLAASAA GEVAPCVLKE 180
QQRQSDEFPT SDISYSSRRT GLPLPPLSCL PMRSCIFNME KSPKSPRHRE RKVPSLSLSV 240
PKLLEPLSRP LSQSAEFSSS KNHQEVTQEG PVEHTLRGSN CTLWSRNMCS FRKSGKQGVA 300
ESWPSQEMEG WDKTKTSGFK EGPSLFSCES VKEDTTPTER ERDSGYHVSE MQRGGEDSQY 360
LSSRKKESWT ARVVERDSGV EHPILCKLLE VSNSEMTPAE EKEIGNENVP DAKSNSVHKS 420
GAMEPHAASE EVSVPKNGPS VNSDGPAEEL EGHRDIEQNR KIPMEEETNP EMNGVVPLTH 480
IAFPGEGTSK GPARAEPHLQ RRKRPAQNSN SFNLLAHREH DKLQTNTHRT KLDSRTKARN 540
RAPPNLMVSI QASIKPNMHK NSIKTQVFPA LELIDHRPHP SSKFQRRAPL TEKKSTHQTQ 600
KPKKQAFPRI GKHAGIKKPG IPLSAETTDP RLHFLDLKYS DMFKEINSAS NGPGIYEMFG 660
TPVYCHIREA ERHDHRCYRE IRTAPSGRCV VNKCQSSESD RCSNSRARLL QKRQHIKPPK 720
PLHGLRQKHR GFISKDKGCK DMGGHTEDSV SEPDGQMKSP GNDFLSSKDD AQLMHLIPIP 780
ELSPEQKAPA PVSDLSIVEE IFTEECADEE GILNDDSLTQ SLGDLKEPEG LHPQAPLVPS 840
ENSWAVLSEK RSGKRVSPEK HNVEPLDKIN AEQMFPGYLE FDSLSEKSKT LVSFSSCSFQ 900
ENLERAPSPT EQHWARSLEQ DSLENNSTTY QTFGKISQEI LDPGKNEELT DELLGCLVEE 960
LLALDEKDNN SCQIMTNEAD AKNLNLVFSR RGNTIEELGR ETTDVKLQRC INGFRIYDEE 1020
NFLTSNEKKT LSDKSLNHEE AIFWTKGEIL GRGAYGTVYC GLTSLGQLIA VKQVALDTSD 1080
KLATEKEYRK LQEEVDLLKA LKHVNIVAYL GTCLEENTLS IFMEFVPGGS ISSIINRFGP 1140
LPEMVFCKYT RQILQGVAYL HDNCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN 1200
GTHSDMLKSM RGTPYWMAPE VINESGYGRK SDIWSIGCTV FEMATGKPPL ASMDRMAAMF 1260
YIGAHRGLMP PLPARFSEPA ADFVRLCLTR DQHERPSALQ LLKHSFLKRS Q 1311 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS