CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Golgi apparatus protein 1 
Protein Synonyms/Alias
 CFR-1; Cysteine-rich fibroblast growth factor receptor; E-selectin ligand 1; ESL-1; Golgi sialoglycoprotein MG-160 
Gene Name
 GLG1 
Gene Synonyms/Alias
 CFR1; ESL1; MG160 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
374KVSYSLAKSCKSDLKubiquitination[1]
516SVIQTACKHIRSGDPubiquitination[1]
558YFISRDWKLDPVLYRubiquitination[1]
630HQRAMDVKLDPALQDubiquitination[1]
638LDPALQDKCLIDLGKubiquitination[1]
831EACKSDIKNFCSAVQubiquitination[2]
1190RSETMAYKGLVWSQDubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils). 
Sequence Annotation
 REPEAT 116 149 Cys-rich GLG1 1.
 REPEAT 150 212 Cys-rich GLG1 2.
 REPEAT 215 278 Cys-rich GLG1 3.
 REPEAT 286 346 Cys-rich GLG1 4.
 REPEAT 347 413 Cys-rich GLG1 5.
 REPEAT 414 473 Cys-rich GLG1 6.
 REPEAT 475 537 Cys-rich GLG1 7.
 REPEAT 538 604 Cys-rich GLG1 8.
 REPEAT 609 668 Cys-rich GLG1 9.
 REPEAT 670 728 Cys-rich GLG1 10.
 REPEAT 729 788 Cys-rich GLG1 11.
 REPEAT 796 856 Cys-rich GLG1 12.
 REPEAT 858 911 Cys-rich GLG1 13.
 REPEAT 912 979 Cys-rich GLG1 14.
 REPEAT 980 1035 Cys-rich GLG1 15.
 REPEAT 1041 1101 Cys-rich GLG1 16.
 CARBOHYD 165 165 N-linked (GlcNAc...) (Potential).
 CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
 CARBOHYD 581 581 N-linked (GlcNAc...) (Potential).
 CARBOHYD 677 677 N-linked (GlcNAc...).
 CARBOHYD 786 786 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Repeat; Sialic acid; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1179 AA 
Protein Sequence
MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG 60
QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE 120
DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC 180
KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD 240
CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE 300
LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK 360
LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ 420
GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC 480
QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE 540
DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA 600
YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL 660
QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC 720
LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL 780
STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG 840
NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM 900
LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD 960
SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE 1020
AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA 1080
AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT 1140
SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDRL QYRSETMAYK GLVWSQDVTG 1200
SPA 1203 
Gene Ontology
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0000139; C:Golgi membrane; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0060349; P:bone morphogenesis; IEA:Compara.
 GO:0010955; P:negative regulation of protein processing; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0032330; P:regulation of chondrocyte differentiation; IEA:Compara. 
Interpro
 IPR001893; Cys-rich_GLG1_repeat.
 IPR017873; Cys-rich_GLG1_repeat_euk. 
Pfam
 PF00839; Cys_rich_FGFR 
SMART
  
PROSITE
 PS51289; GLG1_C_RICH 
PRINTS