UniProt Accession

 2ABB_HUMAN; Q00005; A6NEJ2; A8K102; B3KPD0; B7Z2F2; B7Z304; D3DQF7; D3DQF8; G3V149 

Genbank Protein ID

 M64930; AK056192; AK289717; AK294659; AK295347; AC008728; AC009186; AC010251; AC011386; AC011357; AC091919; AC091924; CH471062; CH471062; CH471062; CH471062; CH471062; CH471062; BC031790; BI490027; BI669304 

Genbank Nucleotide ID

 AAA36493.1; BAG51642.1; BAF82406.1; BAH11838.1; BAH12040.1; EAW61829.1; EAW61831.1; EAW61832.1; EAW61833.1; EAW61834.1; EAW61835.1; AAH31790.1 

Protein Name

 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform 

Protein Synonyms/Alias

 PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta 

Gene Name

 PPP2R2B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	EPEFDYLKSLEIEEK	ubiquitination	[1]
125	WKVSERDKRPEGYNL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). 

Sequence Annotation

 REPEAT 22 61 WD 1.
 REPEAT 87 128 WD 2.
 REPEAT 171 209 WD 3.
 REPEAT 220 260 WD 4.
 REPEAT 279 317 WD 5.
 REPEAT 334 375 WD 6.
 REPEAT 410 442 WD 7.
 MOD_RES 275 275 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphotyrosine (By similarity).
 MOD_RES 298 298 Phosphothreonine (By similarity).  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Spinocerebellar ataxia; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 443 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0033554; P:cellular response to stress; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0034047; P:regulation of protein phosphatase type 2A activity; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0007286; P:spermatid development; IEA:Compara. 

Interpro

 IPR000009; PP2A_PR55.
 IPR018067; PP2A_PR55_CS.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

  

SMART

 SM00320; WD40 

PROSITE

 PS01024; PR55_1
 PS01025; PR55_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00600; PP2APR55.