UniProt Accession

 COA3_HUMAN; Q9Y2R0; A8K498 

Genbank Protein ID

 AF070665; AK290863; AC016889; CH471152; BC002698 

Genbank Nucleotide ID

 AAD20971.1; BAF83552.1; EAW60884.1; AAH02698.1 

Protein Name

 Cytochrome c oxidase assembly protein 3 homolog, mitochondrial 

Protein Synonyms/Alias

 Coiled-coil domain-containing protein 56; Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa 

Gene Name

 COA3 

Gene Synonyms/Alias

 CCDC56; MITRAC12; HSPC009 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	AELAQWQKVLPRRRT	ubiquitination	[1, 2]
93	DELEDEAKAARARAL	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 106 AA 

Protein Sequence

Gene Ontology

 GO:0031305; C:integral to mitochondrial inner membrane; IDA:UniProtKB.
 GO:0033617; P:mitochondrial respiratory chain complex IV assembly; IMP:UniProtKB.
 GO:0070131; P:positive regulation of mitochondrial translation; IMP:UniProtKB. 

Interpro

 IPR018628; Coiled-coil_56. 

Pfam

 PF09813; Coiled-coil_56 

SMART

  

PROSITE

  

PRINTS