CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol transfer protein beta isoform 
Protein Synonyms/Alias
 PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta 
Gene Name
 PITPNB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MVLIKEFRVVLPubiquitination[1, 2]
67KIYHLKSKVPAFVRMubiquitination[2]
86GSLVFHEKAWNAYPYubiquitination[1, 2, 3, 4]
104IVTNEYMKDDFFIKIubiquitination[1]
155QVEPADYKADEDPALubiquitination[4]
169LFQSVKTKRGPLGPNubiquitination[2]
179PLGPNWKKELANSPDubiquitination[1, 2]
201KLVTIKFKWWGLQSKubiquitination[1, 2]
208KWWGLQSKVENFIQKubiquitination[1, 4]
215KVENFIQKQEKRIFTubiquitination[1]
218NFIQKQEKRIFTNFHubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. 
Sequence Annotation
 MOD_RES 215 215 N6-acetyllysine.
 MOD_RES 262 262 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Lipid-binding; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK 60
IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 120
TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE 180
LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM 240
EDIRRMEDET QKELETLRNQ GQVRGTSAAS DE 272 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0015914; P:phospholipid transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR001666; PI_transfer.
 IPR023393; START-like_dom. 
Pfam
 PF02121; IP_trans 
SMART
  
PROSITE
  
PRINTS
 PR00391; PITRANSFER.