CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Caseinolytic peptidase B protein homolog 
Protein Synonyms/Alias
  
Gene Name
 Clpb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
396ELAKQTAKYMHKDAKacetylation[1]
589KELNFWAKRAKQRHNacetylation[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MMLSAVLRRT TPAPRLFLGL IKSPSLQSRG GAYGRGVVTG DRGEPQRLRA AAWVRPGASS 60
TFVPGRGAAT WGRRGERTEI PYLTAASSER GPSPEETLPG QDSWNGVPNK TGLGMWALAM 120
ALVVQCYSKN PSNKDAALME AARANNVQEV RRLLSEGADV NARHKLGWTA LMVASISHNE 180
SVVQVLLAAG ADPNLGDEFS SVYKTANEQG VHSLEDGRQD CASWRMTNQW TSALEFRRWL 240
GVPVGVLVTR EDDFNNRLNH RASFKGCTAL HYAVLADDYS IVKELLDRGA NPLQRNEMGH 300
TPLDYAREGE VMKLLKTSET KYMEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA 360
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV 420
AKFIGSPPGY IGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK 480
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQM SDKITISKNF 540
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL 600
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKHL 660
LKSPELPSPQ AEKRPPTLRL EIIDKDSKTR KLDIQAPLHP EKVCYTI 707 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR013093; ATPase_AAA-2.
 IPR001270; Chaprnin_ClpA/B.
 IPR019489; Clp_ATPase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07724; AAA_2
 PF00023; Ank
 PF12796; Ank_2
 PF10431; ClpB_D2-small 
SMART
 SM00382; AAA
 SM00248; ANK
 SM01086; ClpB_D2-small 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR00300; CLPPROTEASEA.