UniProt Accession

 DPYL2_MOUSE; O08553; Q6P5D0 

Genbank Protein ID

 Y10339; BC062955 

Genbank Nucleotide ID

 CAA71370.1; AAH62955.1 

Protein Name

 Dihydropyrimidinase-related protein 2 

Protein Synonyms/Alias

 DRP-2; Unc-33-like phosphoprotein 2; ULIP-2 

Gene Name

 Dpysl2 

Gene Synonyms/Alias

 Crmp2; Ulip2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MSYQGKKNIPRIT	ubiquitination	[1]
7	*MSYQGKKNIPRITS	ubiquitination	[1]
20	TSDRLLIKGGKIVND	ubiquitination	[1]
56	LIVPGGVKTIEAHSR	acetylation	[2]
56	LIVPGGVKTIEAHSR	ubiquitination	[1]
258	YVTKVMSKSAAEVIA	acetylation	[3]
258	YVTKVMSKSAAEVIA	succinylation	[3]
293	DGSHYWSKNWAKAAA	acetylation	[4]
293	DGSHYWSKNWAKAAA	ubiquitination	[1]
345	TAQKAVGKDNFTLIP	ubiquitination	[1]
368	RMSVIWDKAVVTGKM	acetylation	[2]
368	RMSVIWDKAVVTGKM	ubiquitination	[1]
374	DKAVVTGKMDENQFV	ubiquitination	[1]
423	SVKTISAKTHNSALE	acetylation	[2]
423	SVKTISAKTHNSALE	ubiquitination	[1]
472	SGRYIPRKPFPDFVY	acetylation	[2]
472	SGRYIPRKPFPDFVY	ubiquitination	[1]
480	PFPDFVYKRIKARSR	ubiquitination	[1]
511	CEVSVTPKTVTPASS	ubiquitination	[1]
520	VTPASSAKTSPAKQQ	acetylation	[3]
520	VTPASSAKTSPAKQQ	succinylation	[3]
520	VTPASSAKTSPAKQQ	ubiquitination	[1]
525	SAKTSPAKQQAPPVR	acetylation	[3]
525	SAKTSPAKQQAPPVR	succinylation	[3]
525	SAKTSPAKQQAPPVR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Plays a role in neuronal development and polarity, as well as in neuron projection morphogenesis, axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. 

Sequence Annotation

 MOD_RES 32 32 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 431 431 Phosphotyrosine.
 MOD_RES 462 462 Phosphothreonine.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 499 499 Phosphotyrosine.
 MOD_RES 509 509 Phosphothreonine.
 MOD_RES 514 514 Phosphothreonine; by GSK3-beta.
 MOD_RES 517 517 Phosphoserine.
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 522 522 Phosphoserine; alternate.
 MOD_RES 522 522 Phosphoserine; by DYRK2; alternate (By
 MOD_RES 542 542 Phosphoserine.
 MOD_RES 555 555 Phosphothreonine; by ROCK2 (By  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0007010; P:cytoskeleton organization; IDA:UniProtKB.
 GO:0021772; P:olfactory bulb development; IEA:Compara.
 GO:0014049; P:positive regulation of glutamate secretion; IEA:Compara.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro.
 GO:0045664; P:regulation of neuron differentiation; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0021510; P:spinal cord development; IEA:Compara.
 GO:0048489; P:synaptic vesicle transport; IEA:Compara. 

Interpro

 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 

Pfam

 PF01979; Amidohydro_1 

SMART

  

PROSITE

  

PRINTS