UniProt Accession

 LRIG2_HUMAN; O94898; Q9NSN2 

Genbank Protein ID

 AB018349; AL161998 

Genbank Nucleotide ID

 BAA34526.2; CAB82328.2 

Protein Name

 Leucine-rich repeats and immunoglobulin-like domains protein 2 

Protein Synonyms/Alias

 LIG-2 

Gene Name

 LRIG2 

Gene Synonyms/Alias

 KIAA0806; LIG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
255	RNGISKLKDGAFFGL	ubiquitination	[1]
731	APRLNWTKDDGPLLV	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 41 75 LRRNT.
 REPEAT 76 97 LRR 1.
 REPEAT 98 119 LRR 2.
 REPEAT 121 142 LRR 3.
 REPEAT 145 166 LRR 4.
 REPEAT 168 189 LRR 5.
 REPEAT 193 214 LRR 6.
 REPEAT 216 237 LRR 7.
 REPEAT 240 261 LRR 8.
 REPEAT 264 285 LRR 9.
 REPEAT 288 309 LRR 10.
 REPEAT 312 333 LRR 11.
 REPEAT 336 357 LRR 12.
 REPEAT 360 382 LRR 13.
 REPEAT 387 408 LRR 14.
 REPEAT 411 432 LRR 15.
 DOMAIN 443 494 LRRCT.
 DOMAIN 498 597 Ig-like C2-type 1.
 DOMAIN 602 691 Ig-like C2-type 2.
 DOMAIN 696 785 Ig-like C2-type 3.
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 189 189 N-linked (GlcNAc...) (Potential).
 CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
 CARBOHYD 441 441 N-linked (GlcNAc...) (Potential).
 CARBOHYD 468 468 N-linked (GlcNAc...) (Potential).
 CARBOHYD 514 514 N-linked (GlcNAc...) (Potential).
 CARBOHYD 571 571 N-linked (GlcNAc...) (Potential).
 CARBOHYD 589 589 N-linked (GlcNAc...) (Potential).
 CARBOHYD 687 687 N-linked (GlcNAc...) (Potential).
 CARBOHYD 728 728 N-linked (GlcNAc...) (Potential).
 DISULFID 519 580 By similarity.
 DISULFID 623 675 By similarity.
 DISULFID 717 766 By similarity.  

Keyword

 Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1065 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 

Interpro

 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp. 

Pfam

 PF07679; I-set
 PF00560; LRR_1 

SMART

 SM00409; IG
 SM00408; IGc2
 SM00369; LRR_TYP
 SM00082; LRRCT 

PROSITE

 PS50835; IG_LIKE
 PS51450; LRR 

PRINTS