| Tag | Content |
|---|
| CPLM ID | CPLM-013635 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SH3 domain-containing protein 19 |
Protein Synonyms/Alias | ADAM-binding protein Eve-1; EEN-binding protein; EBP |
Gene Name | SH3D19 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 619 | GANVLSTKVPLKTKK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
Sequence Annotation | DOMAIN 415 470 SH3 1.
DOMAIN 495 554 SH3 2.
DOMAIN 571 630 SH3 3.
DOMAIN 661 720 SH3 4.
DOMAIN 730 789 SH3 5.
REGION 342 358 Interaction with SH3GL1.
MOD_RES 677 677 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 790 AA |
Protein Sequence | MNIMNTEQSQ NSIVSRIKVF EGQTNIETSG LPKKPEITPR SLPPKPTVSS GKPSVAPKPA 60
ANRASGEWDS GTENRLKVTS KEGLTPYPPL QEAGSIPVTK PELPKKPNPG LIRSVNPEIP 120
GRGPLAESSD SGKKVPTPAP RPLLLKKSVS SENPTYPSAP LKPVTVPPRL AGASQAKAYK 180
SLGEGPPANP PVPVLQSKPL VDIDLISFDD DVLPTPSGNL AEESVGSEMV LDPFQLPAKT 240
EPIKERAVQP APTRKPTVIR IPAKPGKCLH EDPQSPPPLP AEKPIGNTFS TVSGKLSNVE 300
RTRNLESNHP GQTGGFVRVP PRLPPRPVNG KTIPTQQPPT KVPPERPPPP KLSATRRSNK 360
KLPFNRSSSD MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMRGDVLV 420
MLKQTENNYL ECQKGEDTGR VHLSQMKIIT PLDEHLRSRP NDPSHAQKPV DSGAPHAVVL 480
HDFPAEQVDD LNLTSGEIVY LLEKIDTDWY RGNCRNQIGI FPANYVKVII DIPEGGNGKR 540
ECVSSHCVKG SRCVARFEYI GEQKDELSFS EGEIIILKEY VNEEWARGEV RGRTGIFPLN 600
FVEPVEDYPT SGANVLSTKV PLKTKKEDSG SNSQVNSLPA EWCEALHSFT AETSDDLSFK 660
RGDRIQILER LDSDWCRGRL QDREGIFPAV FVRPCPAEAK SMLAIVPKGR KAKALYDFRG 720
ENEDELSFKA GDIITELESV DDDWMSGELM GKSGIFPKNY IQFLQIS 767 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005794; C:Golgi apparatus; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0005886; C:plasma membrane; IDA:BHF-UCL. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0007010; P:cytoskeleton organization; IMP:UniProtKB. GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL. GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome. GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |