| Tag | Content |
|---|
| CPLM ID | CPLM-009942 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neural cell adhesion molecule L1-like protein |
Protein Synonyms/Alias | Cell adhesion molecule with homology to L1CAM; Chl1-like protein; Close homolog of L1; Processed neural cell adhesion molecule L1-like protein |
Gene Name | Chl1 |
Gene Synonyms/Alias | Call |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1019 | CTSRGCGKPISEEGA | acetylation | [1] | | 1032 | GATLGEGKYAGLYDD | acetylation | [1] |
|
Reference | [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. J Biol Chem. 2013 Jul 17;. [ PMID: 23864654] |
Functional Description | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. |
Sequence Annotation | DOMAIN 35 124 Ig-like C2-type 1.
DOMAIN 128 223 Ig-like C2-type 2.
DOMAIN 235 328 Ig-like C2-type 3.
DOMAIN 331 417 Ig-like C2-type 4.
DOMAIN 423 510 Ig-like C2-type 5.
DOMAIN 515 607 Ig-like C2-type 6.
DOMAIN 611 707 Fibronectin type-III 1.
DOMAIN 711 804 Fibronectin type-III 2.
DOMAIN 809 911 Fibronectin type-III 3.
DOMAIN 916 1011 Fibronectin type-III 4.
MOTIF 555 558 DGEA.
MOTIF 1182 1186 FIG[AQ]Y.
MOD_RES 1128 1128 Phosphoserine.
MOD_RES 1148 1148 Phosphoserine.
CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
CARBOHYD 225 225 N-linked (GlcNAc...) (Potential).
CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
CARBOHYD 562 562 N-linked (GlcNAc...) (Potential).
CARBOHYD 580 580 N-linked (GlcNAc...) (Potential).
CARBOHYD 767 767 N-linked (GlcNAc...) (Potential).
CARBOHYD 822 822 N-linked (GlcNAc...) (Potential).
CARBOHYD 945 945 N-linked (GlcNAc...) (Potential).
CARBOHYD 1027 1027 N-linked (GlcNAc...) (Potential).
DISULFID 57 109 By similarity.
DISULFID 153 204 By similarity.
DISULFID 262 310 By similarity.
DISULFID 352 401 By similarity.
DISULFID 445 494 By similarity.
DISULFID 536 591 By similarity. |
Keyword | Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Extracellular matrix; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1209 AA |
Protein Sequence | MMELPLCGRG LILSLIFLLL KLSAAEIPLS VQQVPTIVKQ SYVQVAFPFD EYFQIECEAK 60
GNPEPIFSWT KDDKPFDLSD PRIIAANNSG TFKIPNEGHI SHFQGKYRCF ASNRLGTAVS 120
EEIEFIVPGV PKFPKEKIEP IDVEEGDSIV LPCNPPKGLP PLHIYWMNIE LEHIEQDERV 180
YMSQRGDLYF ANVEENDSRN DYCCFAAFPK LRTIVQKMPM KLTVNSLKHA SDSSSSTEIC 240
SQANSIKQRK PKLLLPPAQM GSLSAKTVLK GDTLLLECFA EGLPTPHIQW SKPGSELPEG 300
RATIEVHEKT LKIENISYQD RGNYRCTANN LLGKASHDFH VTVEEPPRWK KKPQSAVYST 360
GSSGILLCEA EGEPQPTIKW RLNGLPIEKH PFPGDFMFPR EISFTNLLPN HTGVYQCEAS 420
NIHGTILANA NIDVIDVIPL IKTKNEENYA TVVGYSAFLH CEYFASPKAT VVWEVADETH 480
PLEGDRYHTH ENGTLEIYRT TEEDAGSYSC WVDNAMGKAV ITANLDIRNA TKLRVSPKNP 540
RIPKSHVLEL YCESQCDSHL KHSLKLSWSK DGEAFEMNGT EDGRIVIDGA YLTISNITAE 600
DQGVYSCSAQ TSLDSTSEKT QVTVLGVPDP PGNLHLSERQ NRSVRLSWEA GDDHNSKISE 660
YIVEFEGNRE EPGKWEELTR VQGEETDVVL SLAPYVRYQF RVTAVNEVGR SHASLPSDHH 720
ETPPAAPDKN PQNIRVQASQ PKEMIIKWEP LKSMEQNGPG LEYKVSWKPQ GAPEEWEEEI 780
VTNHTLRVMT PTVYAPYDVK VQAINQLGSS PDPQPVTLYS GEDYPSTAPV IQRVDVMNST 840
LVKVTWSSIP KETVHGLLRG YQINWWKTKS LLDGRTHPKE VNILRFSGQR NSGMVPSLDP 900
FSEFHLTVLA YNSKGAGPES EPYIFQTPEG VPEQPSFLKV IKVDKDTATL SWGLPKKLNG 960
NLTGYLLQYQ IINDTYELGE LNEINVTTPS KSSWHLSNLN STTKYKFYLR ACTSRGCGKP 1020
ISEEGATLGE GKYAGLYDDI STQGWFIGLM CAIALLTLIL LTICFVKRNR GGKYSVKEKE 1080
DLHPDPEVQS AKDETFGEYR KMVLKQKLLS WSSSRGRTFY SCTKNTLFDG SSVDMKTLQP 1140
LRYFSSNKHT 1150 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |