CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 pH-response regulator protein palF/RIM8 
Protein Synonyms/Alias
 Regulator of IME2 protein 8 
Gene Name
 RIM8 
Gene Synonyms/Alias
 PAL3; YGL045W; YGL046W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
521VSVPSEDKQELEQKRubiquitination[1, 2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth. 
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MSLLRLWNKE SRAPSKIKSH GIVGSYGNSM LAHNNVKQFR IDIDEPHRVW KPNESITGEA 60
VIDIKRDITN VAIKLSLVCE VRVKTGNSPT SKNKRIEKTL EKSTFLYGQD YVKTAFSAKE 120
KKPHVDKTTI LNGLSKGEHR FPFRIRIPRG RGMLSSIKFE RGSITYFLSC TLESLNNING 180
LKKPEARCER EFAVIVPLDV SRLPKPKTKT VVLQSASMVQ NKKNKSTEDE SSSYTQLTQK 240
STTSNSSSSS VNSKTSPLPN KTVTISVDIP QAGFMIGEII PIDVKIDHYK PFYAPAGLTT 300
TLVRICRVGG AGKDDPMETF RKDICQSISP IYINPETLQF QSRVYLKVPL DAFSTLTTVG 360
KFFSFQYYIE VMVNLSKKNV VYTESNRIIG TPIGEQNGLG VENNINRIQR KMLRMVNPET 420
LENDSEGYES SIFFKDMVNV EKLKRLRNVT GMSIETVIGT TRSEQQQSDA SIPSQSSITA 480
PQNSPSNLRD WLAPLNAYDS DDVPVPKYSP NDKVSVPSED KQELEQKRLQ QLESDPPPCD 540
DY 542 
Gene Ontology
 GO:0009898; C:internal side of plasma membrane; IDA:SGD.
 GO:0071467; P:cellular response to pH; IEA:InterPro.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
 GO:0007126; P:meiosis; IMP:SGD.
 GO:0016485; P:protein processing; IMP:SGD.
 GO:0070086; P:ubiquitin-dependent endocytosis; ISA:SGD. 
Interpro
 IPR011021; Arrestin-like_N.
 IPR011022; Arrestin_C-like.
 IPR014756; Ig_E-set.
 IPR027077; pH_reg_PalF/RIM8. 
Pfam
 PF02752; Arrestin_C
 PF00339; Arrestin_N 
SMART
 SM01017; Arrestin_C 
PROSITE
  
PRINTS