UniProt Accession

 D6R9V2_HUMAN; D6R9V2 

Genbank Protein ID

 AC105448; AL132868 

Genbank Nucleotide ID

  

Protein Name

 Histone-lysine N-methyltransferase NSD2 

Protein Synonyms/Alias

  

Gene Name

 WHSC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	LPFIPADKLKDLTSR	acetylation	[1, 2]
198	KISSPSDKKIPAKKE	acetylation	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:Compara.
 GO:0003289; P:atrial septum primum morphogenesis; IEA:Compara.
 GO:0003290; P:atrial septum secundum morphogenesis; IEA:Compara.
 GO:0060348; P:bone development; IEA:Compara.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR000313; PWWP. 

Pfam

 PF00855; PWWP 

SMART

  

PROSITE

 PS50812; PWWP 

PRINTS