CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016207
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-24 
Protein Synonyms/Alias
  
Gene Name
 CDH24 
Gene Synonyms/Alias
 CDH11L; UNQ2834/PRO34009 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
258DVNDNPPKFPQSLYQacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion. 
Sequence Annotation
 DOMAIN 46 150 Cadherin 1.
 DOMAIN 151 259 Cadherin 2.
 DOMAIN 260 374 Cadherin 3.
 DOMAIN 375 517 Cadherin 4.
 DOMAIN 517 630 Cadherin 5.
 CARBOHYD 446 446 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 563 563 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 819 AA 
Protein Sequence
MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ FFVIEEYAGP 60
EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN IHVTKSLDRE EKAQYVLLAQ 120
AVDRASNRPL EPPSEFIIKV QDINDNPPIF PLGPYHATVP EMSNVGTSVI QVTAHDADDP 180
SYGNSAKLVY TVLDGLPFFS VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS 240
GSTTVTVTLS DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LRAQDPDLGD NALMAYSILD 300
GEGSEAFSIS TDLQGRDGLL TVRKPLDFES QRSYSFRVEA TNTLIDPAYL RRGPFKDVAS 360
VRVAVQDAPE PPAFTQAAYH LTVPENKAPG TLVGQISAAD LDSPASPIRY SILPHSDPER 420
CFSIQPEEGT IHTAAPLDRE ARAWHNLTVL ATELGWSWGP ERGWVPLLVA EWSAPAAPPQ 480
RSPVGSAVGI PQDSSAQASR VQVAIQTLDE NDNAPQLAEP YDTFVCDSAA PGQLIQVIRA 540
LDRDEVGNSS HVSFQGPLGP DANFTVQDNR DGSASLLLPS RPAPPRHAPY LVPIELWDWG 600
QPALSSTATV TVSVCRCQPD GSVASCWPEA HLSAAGLSTG ALLAIITCVG ALLALVVLFV 660
ALRRQKQEAL MVLEEEDVRE NIITYDDEGG GEEDTEAFDI TALQNPDGAA PPAPGPPARR 720
DVLPRARVSR QPRPPGPADV AQLLALRLRE ADEDPGVPPY DSVQVYGYEG RGSSCGSLSS 780
LGSGSEAGGA PGPAEPLDDW GPLFRTLAEL YGAKEPPAP 819 
Gene Ontology
 GO:0005911; C:cell-cell junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0016337; P:cell-cell adhesion; IDA:MGI.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.