UniProt Accession

 STK38_HUMAN; Q15208; Q503A1 

Genbank Protein ID

 Z35102; Z85986; BC012085; BC095413 

Genbank Nucleotide ID

 CAA84485.1; CAB39180.1; AAH12085.1; AAH95413.1 

Protein Name

 Serine/threonine-protein kinase 38 

Protein Synonyms/Alias

 NDR1 protein kinase; Nuclear Dbf2-related kinase 1 

Gene Name

 STK38 

Gene Synonyms/Alias

 NDR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	SSMSNHTKERVTMTK	ubiquitination	[1, 2]
72	RRSAHARKETEFLRL	ubiquitination	[2]
93	LEDFESLKVIGRGAF	ubiquitination	[2, 3]
118	TGHVYAMKILRKADM	ubiquitination	[2]
214	GFIHRDIKPDNLLLD	ubiquitination	[3]
227	LDSKGHVKLSDFGLC	ubiquitination	[2]
239	GLCTGLKKAHRTEFY	ubiquitination	[2]
377	APGVEEIKSNSFFEG	ubiquitination	[2, 4]
462	GAIPSYMKAAK****	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. 

Sequence Annotation

 DOMAIN 89 382 Protein kinase.
 DOMAIN 383 455 AGC-kinase C-terminal.
 NP_BIND 95 103 ATP (By similarity).
 REGION 62 87 Interaction with S100B.
 ACT_SITE 212 212 Proton acceptor (By similarity).
 BINDING 118 118 ATP.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 74 74 Phosphothreonine.
 MOD_RES 264 264 Phosphoserine.
 MOD_RES 281 281 Phosphoserine; by autocatalysis.
 MOD_RES 444 444 Phosphothreonine; by STK24/MST3.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0070688; C:MLL5-L complex; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase
 PF00433; Pkinase_C 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS