CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin-7 receptor subunit alpha 
Protein Synonyms/Alias
 IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; CD127 
Gene Name
 IL7R 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337QQLEESEKQRLGGDVubiquitination[1]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). 
Sequence Annotation
 DOMAIN 128 224 Fibronectin type-III.
 MOTIF 217 221 WSXWS motif.
 MOTIF 272 280 Box 1 motif.
 MOD_RES 282 282 Phosphothreonine; by PKC (Potential).
 CARBOHYD 49 49 N-linked (GlcNAc...).
 CARBOHYD 65 65 N-linked (GlcNAc...).
 CARBOHYD 151 151 N-linked (GlcNAc...).
 CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
 CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
 CARBOHYD 233 233 N-linked (GlcNAc...) (Potential).
 DISULFID 42 57
 DISULFID 74 82
 DISULFID 108 118  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; SCID; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 60
DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 120
IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 180
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 240
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 300
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES 360
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 420
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ 459 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0003823; F:antigen binding; TAS:ProtInc.
 GO:0004917; F:interleukin-7 receptor activity; TAS:ProtInc.
 GO:0042100; P:B cell proliferation; IEA:Compara.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0048872; P:homeostasis of number of cells; IEA:Compara.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0002377; P:immunoglobulin production; IEA:Compara.
 GO:0048535; P:lymph node development; IEA:Compara.
 GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0033089; P:positive regulation of T cell differentiation in thymus; IEA:Compara.
 GO:0008361; P:regulation of cell size; IEA:Compara.
 GO:0000018; P:regulation of DNA recombination; TAS:ProtInc.
 GO:0030217; P:T cell differentiation; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR003531; Hempt_rcpt_S_F1_CS.
 IPR013783; Ig-like_fold. 
Pfam
 PF00041; fn3 
SMART
  
PROSITE
 PS50853; FN3
 PS01355; HEMATOPO_REC_S_F1 
PRINTS