UniProt Accession

 CATH_HUMAN; P09668; B2RBK0; Q96NY6; Q9BUM7 

Genbank Protein ID

 X16832; AF426247; AK314698; AC011944; BC002479; X07549; X07549 

Genbank Nucleotide ID

 CAA34734.1; AAL23961.1; BAG37247.1; AAH02479.1; CAA30428.1; CAA30429.1 

Protein Name

 Pro-cathepsin H 

Protein Synonyms/Alias

 Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain 

Gene Name

 CTSH 

Gene Synonyms/Alias

 CPSB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	PQNCSATKSNYLRGT	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Important for the overall degradation of proteins in lysosomes. 

Sequence Annotation

 ACT_SITE 141 141 By similarity.
 ACT_SITE 281 281 By similarity.
 ACT_SITE 301 301 By similarity.
 CARBOHYD 101 101 N-linked (GlcNAc...).
 CARBOHYD 230 230 N-linked (GlcNAc...).
 DISULFID 102 327 By similarity.
 DISULFID 138 181 By similarity.
 DISULFID 172 214 By similarity.
 DISULFID 272 322 By similarity.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0097208; C:alveolar lamellar body; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0001520; C:outer dense fiber; IEA:Compara.
 GO:0004177; F:aminopeptidase activity; IDA:UniProtKB.
 GO:0016505; F:apoptotic protease activator activity; IDA:UniProtKB.
 GO:0004197; F:cysteine-type endopeptidase activity; TAS:UniProtKB.
 GO:0030108; F:HLA-A specific activating MHC class I receptor activity; IDA:UniProtKB.
 GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
 GO:0070324; F:thyroid hormone binding; IDA:UniProtKB.
 GO:0019882; P:antigen processing and presentation; TAS:UniProtKB.
 GO:0010815; P:bradykinin catabolic process; IDA:UniProtKB.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
 GO:0060448; P:dichotomous subdivision of terminal units involved in lung branching; ISS:UniProtKB.
 GO:0070371; P:ERK1 and ERK2 cascade; IDA:UniProtKB.
 GO:0002764; P:immune response-regulating signaling pathway; IDA:UniProtKB.
 GO:0033619; P:membrane protein proteolysis; IDA:UniProtKB.
 GO:0001656; P:metanephros development; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0010813; P:neuropeptide catabolic process; IDA:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
 GO:0031648; P:protein destabilization; IMP:UniProtKB.
 GO:0032526; P:response to retinoic acid; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0043129; P:surfactant homeostasis; IDA:UniProtKB.
 GO:0001913; P:T cell mediated cytotoxicity; ISS:UniProtKB.
 GO:0031638; P:zymogen activation; IDA:UniProtKB. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 

Pfam

 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 

SMART

 SM00848; Inhibitor_I29
 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.