UniProt Accession

 BIEA_MOUSE; Q9CY64; Q3T9C6; Q80WR6; Q9DD21 

Genbank Protein ID

 AK002231; AK010847; AK172620; BC052146 

Genbank Nucleotide ID

 BAB21950.1; BAB27219.1; BAE43098.1; AAH52146.1 

Protein Name

 Biliverdin reductase A 

Protein Synonyms/Alias

 BVR A; Biliverdin-IX alpha-reductase 

Gene Name

 Blvra 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
146	VAGKELLKGSLRFTA	ubiquitination	[1]
247	VPNVGVNKNIFLKDQ	acetylation	[2]
247	VPNVGVNKNIFLKDQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (By similarity). 

Sequence Annotation

 NP_BIND 15 20 NAD or NADP (By similarity).
 NP_BIND 76 79 NAD or NADP (By similarity).
 METAL 279 279 Zinc (Potential).
 METAL 280 280 Zinc (Potential).
 METAL 291 291 Zinc (Potential).
 METAL 292 292 Zinc (Potential).
 BINDING 97 97 NAD or NADP; via carbonyl oxygen (By
 MOD_RES 173 173 Phosphothreonine (By similarity).
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 247 247 N6-acetyllysine (By similarity).
 MOD_RES 252 252 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Metal-binding; NAD; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004074; F:biliverdin reductase activity; IDA:MGI.
 GO:0000166; F:nucleotide binding; ISO:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042167; P:heme catabolic process; ISO:MGI. 

Interpro

 IPR017094; Biliverdin_Rdtase_A.
 IPR015249; Biliverdin_Rdtase_cat.
 IPR016040; NAD(P)-bd_dom.
 IPR000683; Oxidoreductase_N. 

Pfam

 PF09166; Biliv-reduc_cat
 PF01408; GFO_IDH_MocA 

SMART

  

PROSITE

  

PRINTS