CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013811
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 1 regulatory subunit 29 
Protein Synonyms/Alias
 Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; Leucine-rich repeat and fibronectin type-III domain-containing protein 6; Leucine-rich repeat-containing protein 62 
Gene Name
 ELFN2 
Gene Synonyms/Alias
 KIAA1904; LRRC62; PPP1R29 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
458SIVHAAQKLGEPPVLubiquitination[1, 2]
485GEKLPTAKGLEAGLDubiquitination[1, 2, 3]
499DTPKVATKGNYIEVRubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. 
Sequence Annotation
 REPEAT 56 77 LRR 1.
 REPEAT 80 101 LRR 2.
 REPEAT 104 125 LRR 3.
 REPEAT 128 149 LRR 4.
 REPEAT 152 173 LRR 5.
 DOMAIN 185 247 LRRCT.
 DOMAIN 292 379 Fibronectin type-III.
 MOD_RES 475 475 Phosphoserine (By similarity).
 MOD_RES 619 619 Phosphoserine.
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 820 AA 
Protein Sequence
MLRLGLCAAA LLCVCRPGAV RADCWLIEGD KGYVWLAICS QNQPPYETIP QHINSTVHDL 60
RLNENKLKAV LYSSLNRFGN LTDLNLTKNE ISYIEDGAFL GQSSLQVLQL GYNKLSNLTE 120
GMLRGMSRLQ FLFVQHNLIE VVTPTAFSEC PSLISIDLSS NRLSRLDGAT FASLASLMVC 180
ELAGNPFNCE CDLFGFLAWL VVFNNVTKNY DRLQCESPRE FAGYPLLVPR PYHSLNAITV 240
LQAKCRNGSL PARPVSHPTP YSTDAQREPD ENSGFNPDEI LSVEPPASST TDASAGPAIK 300
LHHVTFTSAT LVVIIPHPYS KMYILVQYNN SYFSDVMTLK NKKEIVTLDK LRAHTEYTFC 360
VTSLRNSRRF NHTCLTFTTR DPVPGDLAPS TSTTTHYIMT ILGCLFGMVI VLGAVYYCLR 420
KRRMQEEKQK SVNVKKTILE MRYGADVDAG SIVHAAQKLG EPPVLPVSRM ASIPSMIGEK 480
LPTAKGLEAG LDTPKVATKG NYIEVRTGAG GDGLARPEDD LPDLENGQGS AAEISTIAKE 540
VDKVNQIINN CIDALKLDSA SFLGGGSSSG DPELAFECQS LPAAAAASSA TGPGALERPS 600
FLSPPYKESS HHPLQRQLSA DAAVTRKTCS VSSSGSIKSA KVFSLDVPDH PAATGLAKGD 660
SKYIEKGSPL NSPLDRLPLV PAGSGGGSGG GGGIHHLEVK PAYHCSEHRH SFPALYYEEG 720
ADSLSQRVSF LKPLTRSKRD STYSQLSPRH YYSGYSSSPE YSSESTHKIW ERFRPYKKHH 780
REEVYMAAGH ALRKKVQFAK DEDLHDILDY WKGVSAQQKL 820 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR003961; Fibronectin_type3.
 IPR001611; Leu-rich_rpt.
 IPR019931; LPXTG_anchor. 
Pfam
  
SMART
 SM00060; FN3
 SM00082; LRRCT 
PROSITE
 PS50853; FN3
 PS51450; LRR 
PRINTS