CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dynactin subunit 1 
Protein Synonyms/Alias
 Uncharacterized protein 
Gene Name
 DCTN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
213QVRDLEEKLETLRLKacetylation[1, 2]
484ARVREAQKRVEAAQEubiquitination[3]
501ADYQQTIKKYRQLTAubiquitination[4]
541ETFDFKIKFAETKAHubiquitination[4]
550AETKAHAKAIEMELRubiquitination[4]
601LMPRLICKAELIRKQubiquitination[2, 4, 5]
612IRKQAQEKFELSENCubiquitination[4]
945LKKSLKIKGEELSEAubiquitination[4]
1017EAEKAELKQRLNSQSubiquitination[4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1256 AA 
Protein Sequence
MSAEASARPL RVGSRVEVIG KGHRGTVAYV GATLFATGKW VGVILDEAKG KNDGTVQGRK 60
YFTCDEGHGI FVRQSQIQVF EDGADTTSPE TPDSSASKVL KREGTDTTAK TSKLRGLKPK 120
KAPTARKTTT RRPKPTRPAS TGVAGASSSL GPSGSASAGE LSSSEPSTPA QTPLAAPIIP 180
TPVLTSPGAV PPLPSPSKEE EGLRAQVRDL EEKLETLRLK RAEDKAKLKE LEKHKIQLEQ 240
VQEWKSKMQE QQADLQRRLK EARKEAKEAL EAKERYMEEM ADTADAIEMA TLDKEMAEER 300
AESLQQEVEA LKERVDELTT DLEILKAEIE EKGSDGAASS YQLKQLEEQN ARLKDALVRM 360
RDLSSSEKQE HVKLQKLMEK KNQELEVVRQ QRERLQEELS QAESTIDELK EQVDAALGAE 420
EMVEMLTDRN LNLEEKVREL RETVGDLEAM NEMNDELQEN ARETELELRE QLDMAGARVR 480
EAQKRVEAAQ ETVADYQQTI KKYRQLTAHL QDVNRELTNQ QEASVERQQQ PPPETFDFKI 540
KFAETKAHAK AIEMELRQME VAQANRHMSL LTAFMPDSFL RPGGDHDCVL VLLLMPRLIC 600
KAELIRKQAQ EKFELSENCS ERPGLRGAAG EQLSFAAGLV YSLSLLQATL HRYEHALSQC 660
SVDVYKKVGS LYPEMSAHER SLDFLIELLH KDQLDETVNV EPLTKAIKYY QHLYSIHLAE 720
QPEDCTMQLA DHIKFTQSAL DCMSVEVGRL RAFLQGGQEA TDIALLLRDL ETSCSDIRQF 780
CKKIRRRMPG TDAPGIPAAL AFGPQVSDTL LDCRKHLTWV VAVLQEVAAA AAQLIAPLAE 840
NEGLLVAALE ELAFKASEQI YGTPSSSPYE CLRQSCNILI STMNKLATAM QEGEYDAERP 900
PSKPPPVELR AAALRAEITD AEGLGLKLED RETVIKELKK SLKIKGEELS EANVRLSLLE 960
KKLDSAAKDA DERIEKVQTR LEETQALLRK KEKEFEETMD ALQADIDQLE AEKAELKQRL 1020
NSQSKRTIEG LRGPPPSGIA TLVSGIAGGA IPGQAPGSVP GPGLVKDSPL LLQQISAMRL 1080
HISQLQHENS ILKGAQMKAS LASLPPLHVA KLSHEGPGSE LPAGALYRKT SQLLETLNQL 1140
STHTHVVDIT RTSPAAKSPS AQLMEQVAQL KSLSDTVEKL KDEVLKETVS QRPGATVPTD 1200
FATFPSSAFL RAKEEQQDDT VYMGKVTFSC AAGFGQRHRL VLTQEQLHQL HSRLIS 1256 
Gene Ontology
  
Interpro
 IPR000938; CAP-Gly_domain.
 IPR022157; Dynactin. 
Pfam
 PF01302; CAP_GLY
 PF12455; Dynactin 
SMART
 SM01052; CAP_GLY 
PROSITE
 PS00845; CAP_GLY_1
 PS50245; CAP_GLY_2 
PRINTS