CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acylpyruvase FAHD1, mitochondrial 
Protein Synonyms/Alias
 Fumarylacetoacetate hydrolase domain-containing protein 1 
Gene Name
 Fahd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
5***MASTKPLSRFWEacetylation[1]
112VQDECKKKGLPWTLAacetylation[1]
136SAFVPKEKIPDPHALacetylation[1]
148HALRLWLKVNGELRQacetylation[1]
158GELRQEGKTSSMIFSacetylation[1]
191LILTGTPKGVGAVKEacetylation[1]
197PKGVGAVKENDEIEAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). 
Sequence Annotation
 METAL 68 68 Divalent metal cation (By similarity).
 METAL 70 70 Divalent metal cation (By similarity).
 METAL 99 99 Divalent metal cation (By similarity).  
Keyword
 Calcium; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 221 AA 
Protein Sequence
MASTKPLSRF WEWGKNIVCV GRNYADHVKE MRSTVLSEPV LFLKPSTAYA PEGSPVLMPA 60
YCRNLHHEVE LGVLLGRRGE AVPEAAAMDY VAGYALCLDM TARDVQDECK KKGLPWTLAK 120
SFTSSCPVSA FVPKEKIPDP HALRLWLKVN GELRQEGKTS SMIFSIPYII SYVSKIITLE 180
EGDLILTGTP KGVGAVKEND EIEAGIDGVV SMRFKVERSK Y 221 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0018773; F:acetylpyruvate hydrolase activity; ISS:UniProtKB.
 GO:0047621; F:acylpyruvate hydrolase activity; IEA:EC.
 GO:0034545; F:fumarylpyruvate hydrolase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR002529; Fumarylacetoacetase_C.
 IPR011234; Fumarylacetoacetase_C-rel. 
Pfam
 PF01557; FAA_hydrolase 
SMART
  
PROSITE
  
PRINTS