CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017390
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptopodin 
Protein Synonyms/Alias
  
Gene Name
 SYNPO 
Gene Synonyms/Alias
 KIAA1029 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
723NLSEASGKGAELYARacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). 
Sequence Annotation
 MOTIF 562 565 PPxY motif.
 MOTIF 581 584 PPxY motif.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 501 501 Phosphoserine (By similarity).
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 548 548 Phosphoserine (By similarity).
 MOD_RES 580 580 Phosphoserine.
 MOD_RES 685 685 Phosphoserine.
 MOD_RES 702 702 Phosphoserine.
 MOD_RES 746 746 Phosphothreonine.
 MOD_RES 754 754 Phosphoserine.
 MOD_RES 833 833 Phosphoserine.
 MOD_RES 882 882 Phosphoserine (By similarity).
 CARBOHYD 330 330 N-linked (GlcNAc...).  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 929 AA 
Protein Sequence
MLGPHLPPPP LAPSEGRPTP CAFQIPDGSY RCLALEAEES SGEEGLQGEV GPTDLEEDEG 60
VSRSGDDSAC RVTQGTPQLP KALGIQPPSC SREEQGASQH DDRASQDWDV VKAGQMMTAS 120
PSPGPGPRVA QKPALGRSTS LTEKDLKEAK ARSQQIAAQL TTPPSSNSRG VQLFNRRRQR 180
VNEFTLESHG QRGQKPSQES LRVLPSSLPG HAPGLSLSST SLPEPGPPRH PSPQSPDRGV 240
PGHSMEGYSE EASLLRHLEK VASEEEEVPL VVYLKENAAL LTANGLHLSQ NREAQQSSPA 300
PPPAEVHSPA ADVNQNLASP SATLTTPTSN SSHNPPATDV NQNPPATVVP QSLPLSSIQQ 360
NSSEAQLPSN GTGPASKPST LCADGQPQAP AEEVRCSTLL IDKVSTPATT TSTFSREATL 420
IPSSRPPASD FMSSSLLIDI QPNTLVVSAD QEMSGRAAAT TPTKVYSEVH FTLAKPPSVV 480
NRTARPFGIQ APGGTSQMER SPMLERRHFG EKAPAPQPPS LPDRSPRPQR HIMSRSPMVE 540
RRMMGQRSPA SERRPLGNFT APPTYTETLS TAPLASWVRS PPSYSVLYPS SDPKSSHLKG 600
QAVPASKTGI LEESMARRGS RKSMFTFVEK PKVTPNPDLL DLVQTADEKR RQRDQGEVGV 660
EEEPFALGAE ASNFQQEPAP RDRASPAAAE EVVPEWASCL KSPRIQAKPK PKPNQNLSEA 720
SGKGAELYAR RQSRMEKYVI ESSSHTPELA RCPSPTMSLP SSWKYPTNAP GAFRVASRSP 780
ARTPPASLYH GYLPENGVLR PEPTKQPPYQ LRPSLFVLSP IKEPAKVSPR AASPAKPSSL 840
DLVPNLPKGA LPPSPALPRP SRSSPGLYTS PGQDSLQPTA VSPPYGGDIS PVSPSRAWSP 900
RAKQAPRPSF STRNAGIEAQ VWKPSFCFK 929 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0043197; C:dendritic spine; TAS:UniProtKB.
 GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0032233; P:positive regulation of actin filament bundle assembly; IEA:Compara.
 GO:0051492; P:regulation of stress fiber assembly; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS