CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-Va 
Protein Synonyms/Alias
 Dilute myosin heavy chain, non-muscle 
Gene Name
 Myo5a 
Gene Synonyms/Alias
 Dilute 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
979QLSEEEAKVATGRVLubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. 
Sequence Annotation
 DOMAIN 1 765 Myosin head-like.
 DOMAIN 766 788 IQ 1.
 DOMAIN 789 813 IQ 2.
 DOMAIN 814 836 IQ 3.
 DOMAIN 837 861 IQ 4.
 DOMAIN 862 884 IQ 5.
 DOMAIN 885 913 IQ 6.
 DOMAIN 1532 1808 Dilute.
 NP_BIND 163 170 ATP (Potential).
 REGION 643 665 Actin-binding (Potential).
 MOD_RES 600 600 Phosphoserine.
 MOD_RES 1032 1032 Phosphothreonine (By similarity).
 MOD_RES 1450 1450 Phosphoserine (By similarity).
 MOD_RES 1758 1758 Phosphothreonine (Potential).  
Keyword
 3D-structure; Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1853 AA 
Protein Sequence
MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY RLDPKTGELP 60
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 120
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 180
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 240
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADSFHYTKQ GGSPMIEGVD 300
DAKEMAHTRQ ACTLLGISES YQMGIFRILA GILHLGNVGF ASRDSDSCTI PPKHEPLTIF 360
CDLMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDHVN 420
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 480
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK 540
PRMSNKAFII KHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS 600
PTSATSSGRT PLTRVPVKPT KGRPGQTAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC 660
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL 720
GDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW 780
LLRKRYLCMQ RAAITVQRYV RGYQARCYAK FLRRTKAATT IQKYWRMYVV RRRYKIRRAA 840
TIVIQSYLRG YLTRNRYRKI LREYKAVIIQ KRVRGWLART HYKRTMKAIV YLQCCFRRMM 900
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLMEKL TNLEGVYNSE 960
TEKLRNDVER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKSIE ERADKYKQET 1020
DQLVSNLKEE NTLLKQEKET LNHRIVEQAK EMTETMERKL VEETKQLELD LNDERLRYQN 1080
LLNEFSRLEE RYDDLKEEMT LMLNVPKPGH KRTDSTHSSN ESEYTFSSEF AETEDIAPRT 1140
EEPIEKKVPL DMSLFLKLQK RVTELEQEKQ LMQDELDRKE EQVFRSKAKE EERPQIRGAE 1200
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD 1260
VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR 1320
LLESQLQSQK RSHENEAEAL RGEIQSLKEE NNRQQQLLAQ NLQLPPEARI EASLQHEITR 1380
LTNENLYFEE LYADDPKKYQ SYRISLYKRM IDLMEQLEKQ DKTVRKLKKQ LKVFAKKIGE 1440
LEVGQMENIS PGQIIDEPIR PVNIPRKEKD FQGMLEYKRE DEQKLVKNLI LELKPRGVAV 1500
NLIPGLPAYI LFMCVRHADY LNDDQKVRSL LTSTINSIKK VLKKRGDDFE TVSFWLSNTC 1560
RFLHCLKQYS GEEGFMKHNT SRQNEHCLTN FDLAEYRQVL SDLAIQIYQQ LVRVLENILQ 1620
PMIVSGMLEH ETIQGVSGVK PTGLRKRTSS IADEGTYTLD SILRQLNSFH SVMCQHGMDP 1680
ELIKQVVKQM FYIVGAITLN NLLLRKDMCS WSKGMQIRYN VSQLEEWLRD KNLMNSGAKE 1740
TLEPLIQAAQ LLQVKKKTDD DAEAICSMCN ALTTAQIVKV LNLYTPVNEF EERVSVSFIR 1800
TIQMRLRDRK DSPQLLMDAK HIFPVTFPFN PSSLALETIQ IPASLGLGFI ARV 1853 
Gene Ontology
 GO:0042641; C:actomyosin; IDA:MGI.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0032593; C:insulin-responsive compartment; IDA:UniProtKB.
 GO:0005882; C:intermediate filament; IDA:MGI.
 GO:0042470; C:melanosome; IDA:MGI.
 GO:0035371; C:microtubule plus end; IDA:MGI.
 GO:0016459; C:myosin complex; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0001750; C:photoreceptor outer segment; IDA:MGI.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0005516; F:calmodulin binding; IDA:MGI.
 GO:0000146; F:microfilament motor activity; IDA:MGI.
 GO:0042640; P:anagen; IMP:MGI.
 GO:0032869; P:cellular response to insulin stimulus; IMP:UniProtKB.
 GO:0051643; P:endoplasmic reticulum localization; IMP:MGI.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0030073; P:insulin secretion; IMP:MGI.
 GO:0031987; P:locomotion involved in locomotory behavior; IMP:MGI.
 GO:0042759; P:long-chain fatty acid biosynthetic process; IMP:MGI.
 GO:0042438; P:melanin biosynthetic process; IMP:MGI.
 GO:0030318; P:melanocyte differentiation; IMP:MGI.
 GO:0032402; P:melanosome transport; IDA:MGI.
 GO:0042552; P:myelination; IMP:MGI.
 GO:0042476; P:odontogenesis; IDA:MGI.
 GO:0072659; P:protein localization to plasma membrane; IMP:UniProtKB.
 GO:0031585; P:regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IMP:MGI.
 GO:0032252; P:secretory granule localization; IMP:MGI.
 GO:0050808; P:synapse organization; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI.
 GO:0030050; P:vesicle transport along actin filament; TAS:MGI.
 GO:0007601; P:visual perception; IMP:MGI. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01843; DIL
 PF00612; IQ
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS51126; DILUTE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.