UniProt Accession

 ETFB_HUMAN; P38117; B3KNY2; Q6IBH7; Q71RF6; Q9Y3S7 

Genbank Protein ID

 X71129; AF436663; AF436658; AF436659; AF436660; AF436661; AF436662; AF370381; CR456827; AK055285; BC093961; BC093963; X76067 

Genbank Nucleotide ID

 CAA50441.1; AAN03713.1; AAN03713.1; AAN03713.1; AAN03713.1; AAN03713.1; AAN03713.1; AAQ15217.1; CAG33108.1; BAG51494.1; AAH93961.1; AAH93963.1; CAB37832.1 

Protein Name

 Electron transfer flavoprotein subunit beta 

Protein Synonyms/Alias

 Beta-ETF 

Gene Name

 ETFB 

Gene Synonyms/Alias

 FP585 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	RVIDYAVKIRVKPDR	ubiquitination	[1]
35	GVVTDGVKHSMNPFC	ubiquitination	[1]
110	QVARVLAKLAEKEKV	acetylation	[2]
110	QVARVLAKLAEKEKV	ubiquitination	[1, 3]
114	VLAKLAEKEKVDLVL	ubiquitination	[1]
116	AKLAEKEKVDLVLLG	acetylation	[2]
116	AKLAEKEKVDLVLLG	ubiquitination	[1]
176	GLETLRLKLPAVVTA	ubiquitination	[1]
202	LPNIMKAKKKKIEVI	ubiquitination	[1]
210	KKKIEVIKPGDLGVD	acetylation	[4]
210	KKKIEVIKPGDLGVD	ubiquitination	[1]
248	TTEDLVAKLKEIGRI	acetylation	[2]
250	EDLVAKLKEIGRI**	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Electron transport; FAD; Flavoprotein; Glutaricaciduria; Mitochondrion; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 255 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0009055; F:electron carrier activity; TAS:ProtInc.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000049; ET-Flavoprotein_bsu_CS.
 IPR014730; ETF_a/b_N.
 IPR012255; ETF_b.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01012; ETF 

SMART

 SM00893; ETF 

PROSITE

 PS01065; ETF_BETA 

PRINTS