CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone-lysine N-methyltransferase eggless 
Protein Synonyms/Alias
 SETDB1 homolog 
Gene Name
 egg 
Gene Synonyms/Alias
 CG12196 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
80KQCPYGGKAPDEPGKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis. 
Sequence Annotation
 DOMAIN 529 602 Tudor 1.
 DOMAIN 629 686 Tudor 2.
 DOMAIN 818 884 MBD.
 DOMAIN 946 1018 Pre-SET.
 DOMAIN 1021 1237 SET.
 DOMAIN 1246 1262 Post-SET.
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 217 217 Phosphothreonine.  
Keyword
 Chromatin regulator; Chromosome; Coiled coil; Complete proteome; Developmental protein; Differentiation; Methyltransferase; Nucleus; Oogenesis; Phosphoprotein; Reference proteome; Repeat; Repressor; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1262 AA 
Protein Sequence
MSGQPTAVDC LESSGSTVED VQETPASREK SYGLPVRKGE NSLESPAEQA AKDVEIEELT 60
HSEAIAATGS TRKQCPYGGK APDEPGKLAD ESEDRKGENT KAIASSPVLV AVDSDSSVEL 120
IESPVKFSSA NESEKDPPKP DAVNEAAAKE AEEMTDSSIS SPTSESFPEK DEKTNKENEQ 180
EPPGMEVDQD VEESISRPAE EYKIENTLKG HKRISLTEIE EHKIVDKKDD VLEVELEKGT 240
APKAAEDEKL NALLSDGDVF YDKECVNCNC TKLHKQYVLA NMATLNFYQV LRKSSKQQFL 300
CMGCHDTAMD LYEEYAGQLM AKQPLLLKDF HQDHADFVAL DSSDEEEEEK QPEKSDFSKN 360
KLQLIEDELD DAIKNVLNKV DFTAQLSWSK TILQAKADHL ERQFALADVE LEKVQTTADK 420
MHCALYNSCP VAHKHLPTLD IEPSDYVHEV PPPGEIVRPP IQLGETYYAV KNKAIASWVS 480
IKVIEFTEST AINGNTMKSY KIRYLNTPYQ MIKTVTAKHI AYFEPPPVRL TIGTRVIAYF 540
DGTTLSRGKD KGVVQSAFYP GIIAEPLKQA NRYRYLIFYD DGYTQYVPHR DVRLVCQASE 600
KVWEDVHAAS RDFIQKYVEK YSVDRPMVQC TRGQSMTTES NGTWLYARVI DIDCSLVLMQ 660
FEGDKNHTEW IYRGSLRLGP VFRETQNNMN SSSAQQLRVP RRTEPFIRYT KEMESSSKVN 720
QQMRAFARKS SASAQNNALA AASSAATPAG GRTNAGGVST SNSASAVRHL NNSTIYVDDE 780
NRPKGHVVYF TAKRNLPPKM YKCHECSPNC LFKIVHRLDS YSPLAKPLLS GWERLVMRQK 840
TKKSVVYKGP CGKSLRSLAE VHRYLRATEN VLNVDNFDFT PDLKCLAEYS IDPSIVKDTD 900
ISKGQEKMAI PLVNYYDNTL PPPCTYAKQR IPTEGVHLNL DEEFLLCCDC EDDCSDKSKC 960
ACWQLTVAGV RYCNPKKPIE EIGYQYKRLH EHVPTGIYEC NSRCKCKKNC LNRVVQFSLE 1020
MKLQVFKTSN RGWGLRCVND IPKGAFICIY AGHLLTETMA NEGGQDAGDE YFADLDYIEV 1080
AEQLKEGYES EVDHSDPDAE EDNGGPDAED DDDFRPNYHY QRKIKRSSRS GSTQNSSTQS 1140
SELDSQERAV INFNPNADLD ETVRENSVRR LFGKDEAPYI MDAKTTGNLG RYFNHSCSPN 1200
LFVQNVFVDT HDLRFPWVAF FSAAHIRSGT ELTWNYNYEV GVVPGKVLYC QCGAPNCRLR 1260
LL 1262 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0010385; F:double-stranded methylated DNA binding; IDA:FlyBase.
 GO:0046974; F:histone methyltransferase activity (H3-K9 specific); IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0044026; P:DNA hypermethylation; IMP:FlyBase.
 GO:0048132; P:female germ-line stem cell division; IDA:FlyBase.
 GO:0002165; P:instar larval or pupal development; IMP:FlyBase.
 GO:0045814; P:negative regulation of gene expression, epigenetic; IDA:FlyBase.
 GO:0051038; P:negative regulation of transcription during meiosis; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0035220; P:wing disc development; IMP:FlyBase. 
Interpro
 IPR016177; DNA-bd_integrase-typ.
 IPR001739; Methyl_CpG_DNA-bd.
 IPR003616; Post-SET_dom.
 IPR007728; Pre-SET_dom.
 IPR001214; SET_dom. 
Pfam
 PF01429; MBD
 PF05033; Pre-SET
 PF00856; SET 
SMART
 SM00317; SET 
PROSITE
 PS50982; MBD
 PS50868; POST_SET
 PS50867; PRE_SET
 PS50280; SET
 PS50304; TUDOR 
PRINTS