CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031548
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein OS-9 
Protein Synonyms/Alias
 cDNA FLJ58567, highly similar to Homo sapiens amplified in osteosarcoma (OS9), transcript variant 2, mRNA 
Gene Name
 OS9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66DVVIVSSKYKQRYECubiquitination[1]
113RDAPCLLKTKDWWTYubiquitination[2]
115APCLLKTKDWWTYEFubiquitination[3]
171EELKGGTKKGKPNIGubiquitination[3]
174KGGTKKGKPNIGQEQubiquitination[2, 4]
301LIKRLEEKQSPELVKubiquitination[2]
333PTGKIEIKIVRPWAEubiquitination[3]
358DEDTRNLKEIFFNILubiquitination[2, 4, 5]
380QKERQRQKELESNYRubiquitination[2, 3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MAAETLLSSL LGLLLLGLLL PASLTGGVGS LNLEELSEMR YGIEILPLPV MGGQSQSSDV 60
VIVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE LLSPMRDAPC LLKTKDWWTY 120
EFCYGRHIQQ YHMEDSASGA PNDFQNNVQV KVIRSPADLI RFIEELKGGT KKGKPNIGQE 180
QPVDDAAEVP QREPEKERGD PERQREMEEE EDEDEDEDED EDERQLLGEF EKELEGILLP 240
SDRDRLRSEV KAGMERELEN IIQETEKELD PDGLKKESER DRAMLALTST LNKLIKRLEE 300
KQSPELVKKH KKKRVVPKKP PPSPQPTGKI EIKIVRPWAE GTEEGARWLT DEDTRNLKEI 360
FFNILVPGAE EAQKERQRQK ELESNYRRVW GSPGGEGTGD LDEFDF 406 
Gene Ontology
  
Interpro
 IPR012913; PRKCSH. 
Pfam
 PF07915; PRKCSH 
SMART
  
PROSITE
  
PRINTS