UniProt Accession

 AHPC_ECOLI; P0AE08; P26427 

Genbank Protein ID

 D13187; U82598; U00096; AP009048 

Genbank Nucleotide ID

 BAA02485.1; AAB40806.1; AAC73706.1; BAA35235.1 

Protein Name

 Alkyl hydroperoxide reductase subunit C 

Protein Synonyms/Alias

 Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase 

Gene Name

 ahpC 

Gene Synonyms/Alias

 b0605; JW0598 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
7	*MSLINTKIKPFKNQ	acetylation	[1]
12	NTKIKPFKNQAFKNG	acetylation	[1, 2]
17	PFKNQAFKNGEFIEI	acetylation	[1, 2, 3]
27	EFIEITEKDTEGRWS	acetylation	[2]
80	TDTHFTHKAWHSSSE	acetylation	[2]
91	SSSETIAKIKYAMIG	acetylation	[1, 2]
93	SETIAKIKYAMIGDP	acetylation	[1, 2, 3]
151	DASDLLRKIKAAQYV	acetylation	[1]
153	SDLLRKIKAAQYVAS	acetylation	[1, 2, 3]
169	PGEVCPAKWKEGEAT	acetylation	[1, 2, 3]
171	EVCPAKWKEGEATLA	acetylation	[1, 2, 3]
186	PSLDLVGKI******	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Directly reduces organic hydroperoxides in its reduced dithiol form. 

Sequence Annotation

 DOMAIN 2 157 Thioredoxin.
 ACT_SITE 47 47 Cysteine sulfenic acid (-SOH)
 MOD_RES 17 17 N6-acetyllysine.
 MOD_RES 93 93 N6-acetyllysine.
 MOD_RES 153 153 N6-acetyllysine.
 MOD_RES 169 169 N6-acetyllysine.
 MOD_RES 171 171 N6-acetyllysine.
 DISULFID 47 47 Interchain (with C-166); in linked form
 DISULFID 166 166 Interchain (with C-47); in linked form  

Keyword

 Acetylation; Antioxidant; Complete proteome; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0032843; F:hydroperoxide reductase activity; IDA:EcoliWiki.
 GO:0004601; F:peroxidase activity; IGI:EcoliWiki.
 GO:0051920; F:peroxiredoxin activity; IEA:EC.
 GO:0009970; P:cellular response to sulfate starvation; IDA:EcoliWiki.
 GO:0033195; P:response to alkyl hydroperoxide; IMP:EcoCyc. 

Interpro

 IPR017559; AhpC.
 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS