UniProt Accession

 NDE1_HUMAN; Q9NXR1; Q49AQ2 

Genbank Protein ID

 AK000108; AC026401; AF001548; BC001421; BC033900 

Genbank Nucleotide ID

 BAA90949.1; AAH01421.1; AAH33900.1 

Protein Name

 Nuclear distribution protein nudE homolog 1 

Protein Synonyms/Alias

 NudE 

Gene Name

 NDE1 

Gene Synonyms/Alias

 NUDE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
270	KVGALESKLASCRNL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. 

Sequence Annotation

 REGION 1 93 Self-association (By similarity).
 REGION 88 156 Interaction with PAFAH1B1 (By
 REGION 167 290 Interaction with CENPF (By similarity).
 MOD_RES 211 211 Phosphoserine.
 MOD_RES 215 215 Phosphothreonine.
 MOD_RES 228 228 Phosphothreonine.
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 239 239 Phosphoserine.
 MOD_RES 243 243 Phosphothreonine.
 MOD_RES 246 246 Phosphothreonine.
 MOD_RES 282 282 Phosphoserine.
 LIPID 274 274 S-palmitoyl cysteine; by ZDHHC2, ZDHHC3  

Keyword

 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Kinetochore; Lipoprotein; Lissencephaly; Microtubule; Mitosis; Neurogenesis; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
 GO:0008017; F:microtubule binding; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051298; P:centrosome duplication; ISS:UniProtKB.
 GO:0021987; P:cerebral cortex development; IMP:UniProtKB.
 GO:0051303; P:establishment of chromosome localization; IMP:UniProtKB.
 GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007020; P:microtubule nucleation; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007405; P:neuroblast proliferation; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara. 

Interpro

 IPR006964; NUDE_C. 

Pfam

 PF04880; NUDE_C 

SMART

  

PROSITE

  

PRINTS