| Tag | Content |
|---|
| CPLM ID | CPLM-018685 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleiotropic regulator 1 |
Protein Synonyms/Alias | |
Gene Name | Plrg1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | IMETGNTKNSALMAK | ubiquitination | [1] | | 236 | IWDLASGKLKLSLTG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). |
Sequence Annotation | REPEAT 201 240 WD 1.
REPEAT 243 282 WD 2.
REPEAT 285 324 WD 3.
REPEAT 327 366 WD 4.
REPEAT 369 409 WD 5.
REPEAT 410 448 WD 6.
REPEAT 459 498 WD 7.
MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 513 AA |
Protein Sequence | MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNATDSYPHK QYPANQGQDV EYLVTGTHPY PAGPGVALTA DTKIQRMPSE 120
SAAQSLAVAL PSQTRVDANR TGPAGSEYRH PGASDRSQPT AMNSIMETGN TKNSALMAKK 180
APTMPKPQWH PPWKLYRVIS GHLGWVRCIA VEPGNQWFVT GSADRTIKIW DLASGKLKLS 240
LTGHISTVRG VIVSTRSPYL FSCGEDKQVK CWDLEYNKVI RHYHGHLSAV YGLDLHPTLD 300
VLVTCSRDST ARIWDVRTKA SVHTLSGHTN AVATVRCQAA EPQIITGSHD TTIRLWDLVA 360
GKTRVTLTNH KKSVRAVVLH PLLYTFASGS PDNIKQWKFP DGGFIQNLSG HNAIINTLAV 420
NADGVLVSGA DNGTMHLWDW RTGYNFQRVH AAVQPGSLDS ESGIFACAFD RSESRLLTAE 480
ADKTIKVYRE DETATEETHP VSWKPEIIKR KRF 513 |
Gene Ontology | GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |